Cited 29 times in
18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer.
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 허혁 | - |
dc.date.accessioned | 2014-12-20T16:21:15Z | - |
dc.date.available | 2014-12-20T16:21:15Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92559 | - |
dc.description.abstract | BACKGROUND: This study aims to evaluate the efficacy of (18)F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. METHODS: Maximum standardized uptake value (SUV) was measured for 37 patients who underwent (18)F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. RESULTS: A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). CONCLUSIONS: (18)F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 17~24 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma*/diagnostic imaging | - |
dc.subject.MESH | Adenocarcinoma*/drug therapy | - |
dc.subject.MESH | Adenocarcinoma*/pathology | - |
dc.subject.MESH | Adenocarcinoma*/radiotherapy | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Agents/administration & dosage | - |
dc.subject.MESH | Camptothecin/administration & dosage | - |
dc.subject.MESH | Camptothecin/analogs & derivatives | - |
dc.subject.MESH | Colectomy | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Positron-Emission Tomography/methods* | - |
dc.subject.MESH | Preoperative Period | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Radiopharmaceuticals* | - |
dc.subject.MESH | Rectal Neoplasms*/diagnostic imaging | - |
dc.subject.MESH | Rectal Neoplasms*/drug therapy | - |
dc.subject.MESH | Rectal Neoplasms*/pathology | - |
dc.subject.MESH | Rectal Neoplasms*/radiotherapy | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | 18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Jung Bai Ahn | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.identifier.doi | 10.1002/jso.21736 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A04373 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 20886551 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jso.21736/abstract | - |
dc.subject.keyword | rectal cancer | - |
dc.subject.keyword | preoperative chemoradiation therapy | - |
dc.subject.keyword | 18F-FDG PET | - |
dc.subject.keyword | treatment response assessment | - |
dc.subject.keyword | pathologic complete response | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Kang Young | - |
dc.contributor.alternativeName | Hur, Hyuk | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Lee, Kang Young | - |
dc.contributor.affiliatedAuthor | Hur, Hyuk | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 103 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 24 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.103(1) : 17-24, 2011 | - |
dc.identifier.rimsid | 28633 | - |
dc.type.rims | ART | - |
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