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중독성 약물에 대한 보상 기억에서 PKMzeta의 역할

Other Titles
 The Role of PKMzeta in Drug Reward Memory 
Authors
 송민지  ;  김정훈 
Citation
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.23(3) : 83-87, 2012 
Journal Title
Korean Journal of Psychopharmacology(대한정신약물학회지)
ISSN
 1017-5717 
Issue Date
2012
Keywords
중독 ; 보상 기억 ; 중격측좌핵 ; PKMzeta ; Addiction ; Reward memory ; Nucleus accumbens ; CPP ; CPA
Abstract
Drug addiction is a chronic brain disease with a high incidence of relapse. Environmental cues that previously and repeatedly associated with drugs of abuse easily evoke relapse to addicts even after long period of drug-free state. Such a long lasting property of conditioning is considered a form of long-term memory and has a strong correlation with synaptic plasticity like long-term potentiation (LTP). Protein kinase M zeta (PKMzeta) has been known to play an important role in the maintenance of long-term memory as well as LTP in various brain areas. Likewise, in a few brain areas examined out of the rewarding circuit, PKMzeta seems to play a similarly important role in the maintenance of conditioned memory. These results suggest that PKMzeta may become a new target to manipulate to reverse pre-formed drug-related memory and accompanied behaviors.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010023455868
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Hoon(김정훈) ORCID logo https://orcid.org/0000-0001-7095-3729
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92338
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