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중독성 약물에 대한 보상 기억에서 PKMzeta의 역할
DC Field | Value | Language |
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dc.contributor.author | 김정훈 | - |
dc.date.accessioned | 2014-12-19T17:56:11Z | - |
dc.date.available | 2014-12-19T17:56:11Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1017-5717 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92338 | - |
dc.description.abstract | Drug addiction is a chronic brain disease with a high incidence of relapse. Environmental cues that previously and repeatedly associated with drugs of abuse easily evoke relapse to addicts even after long period of drug-free state. Such a long lasting property of conditioning is considered a form of long-term memory and has a strong correlation with synaptic plasticity like long-term potentiation (LTP). Protein kinase M zeta (PKMzeta) has been known to play an important role in the maintenance of long-term memory as well as LTP in various brain areas. Likewise, in a few brain areas examined out of the rewarding circuit, PKMzeta seems to play a similarly important role in the maintenance of conditioned memory. These results suggest that PKMzeta may become a new target to manipulate to reverse pre-formed drug-related memory and accompanied behaviors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 83~87 | - |
dc.relation.isPartOf | Korean Journal of Psychopharmacology (대한정신약물학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 중독성 약물에 대한 보상 기억에서 PKMzeta의 역할 | - |
dc.title.alternative | The Role of PKMzeta in Drug Reward Memory | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | 송민지 | - |
dc.contributor.googleauthor | 김정훈 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00908 | - |
dc.relation.journalcode | J02107 | - |
dc.identifier.pmid | 중독 ; 보상 기억 ; 중격측좌핵 ; PKMzeta ; Addiction ; Reward memory ; Nucleus accumbens ; CPP ; CPA | - |
dc.identifier.url | http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010023455868 | - |
dc.subject.keyword | 중독 | - |
dc.subject.keyword | 보상 기억 | - |
dc.subject.keyword | 중격측좌핵 | - |
dc.subject.keyword | PKMzeta | - |
dc.subject.keyword | Addiction | - |
dc.subject.keyword | Reward memory | - |
dc.subject.keyword | Nucleus accumbens | - |
dc.subject.keyword | CPP | - |
dc.subject.keyword | CPA | - |
dc.contributor.alternativeName | Kim, Jeong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hoon | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 87 | - |
dc.identifier.bibliographicCitation | Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.23(3) : 83-87, 2012 | - |
dc.identifier.rimsid | 29429 | - |
dc.type.rims | ART | - |
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