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Acetaminophen 중독 환자에서 N-Acetylcysteine 투여경로에 따른 치료효과 및 부작용 비교

Other Titles
 Oral vs. Intravenous Administration of N-acetylcysteine in the Acetaminophen Poisoning 
Authors
 채효주  ;  이누가  ;  김현종  ;  유제성  ;  정성필  ;  이한식 
Citation
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.10(2) : 97-102, 2012 
Journal Title
Journal of the Korean Society of Clinical Toxicology(대한임상독성학회지)
ISSN
 1738-1320 
Issue Date
2012
Keywords
Poisoning ; Acetaminophen ; N-Acetylcysteine
Abstract
Purpose: Serious acetaminophen (AAP) poisoning causes hepatotoxicity. N-acetylcysteine (NAC) is the most effective therapy for AAP poisoning and can be administered orally and intravenously (IV). Several studies have compared the efficacy of these two routes of administration and the results have been controversial. The purpose of this study was to compare the efficacy of oral and IV NAC for the prevention of hepatic toxicity in Korean patients whose serum AAP levels were higher than normal. Methods: A retrospective before/after study was performed, in which the patients presented to the emergency department with an AAP overdose from February 1995 to March 2012. A 3-day oral NAC regimen was used in the beginning, and a 20-hr intravenous regimen was then used from 2007. This study assessed the complications of an AAP overdose, such as hepatotoxicity, hepatic failure and renal failure as well as the side effects of the treatment regimen. Results: A total of 41patients was enrolled in this study. The median ALT and AST were 63 (IU/L) and 57 (IU/L) for the oral NAC treated patients, and 14 (IU/L) and 20 (IU/L) for the IV NAC treated patients (p=0.004 and p=0.001, respectively). The incidence of complications was similar in the treatment groups (p=0.399). Among the patients, 7 patients developed hepatotoxicity and were treated successfully with oral or IV NAC. Conclusion: This study suggests that IV NAC and oral NAC can prevent and successfully treat hepatic toxicity in patients whose serum AAP levels are higher than normal.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Jong(김현종)
You, Je Sung(유제성) ORCID logo https://orcid.org/0000-0002-2074-6745
Rhee, Nu Ga(이누가)
Lee, Hahn Shick(이한식)
Chung, Sung Phil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92328
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