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미숙아 망막병증을 가진 극소 저체중 출생아에서 수술의 위험인자

Other Titles
 Risk of Surgery for Retinopathy of Prematurity in Very Low Birht Weight Infants 
Authors
 김남효 ; 이순민 ; 이철 ; 남궁란 ; 박국인 ; 박민수 ; 은호선 
Citation
 대한신생아학회지, Vol.19(2) : 71~76, 2012 
Journal Title
 대한신생아학회지 
ISSN
 1226-1513 
Issue Date
2012
Abstract
Purpose: The main postnatal risk factors of retinopathy of prematurity (ROP) were described as prolonged oxygen therapy and lower gestational age. Recent data suggest poor early weight gain during the first weeks of life, which can be an additional predictor of severe ROP. We aimed to analyze the risk factors associated with requiring operation for ROP in preterm infants with very low birth weight (VLBW). Methods: In a retrospective case control study, from January 2004 to June 2010, 140 VLBW infants diagnosed as ROP by the International classification of ROP were recruited. There were 14% of infants with stage 1 disease, 65.7% stage 2, and 20% stage 3 or more. A group requiring a laser surgery for ROP was 66 infants, and a group not requiring surgery was 74 infants. Results: By a univariate analysis, antenatal steroid, chorioamnionitis, gestational age, birth weight, days on oxygen, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalasia and sepsis were significantly associated with ROP requiring surgery. Weight differences between birth and each from 4 to 12 weeks were significantly lower in the infants requiring surgery (P<0.05). However, after adjustment for gestational age in logistic regression, weight difference between birth and 8th week was a significant predictive factor for the requirement of surgery in infants with ROP (OR, 0.998; 95% CI, 0.996-0.999, P=0.013). Conclusion: We suggest that careful monitoring of weight change and aggresive nutritional support for poorly growing infants, during the first 8 weeks of life, may possibly prevent laser surgery of ROP in preterm VLBW infants.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92277
DOI
10.5385/jksn.2012.19.2.71
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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