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건강한 청소년에서 맥압과 경동맥 내중막 두께의 관련성

Other Titles
 Association between Pulse Pressure and Carotid Intima-Media Thickness in Healthy Adolescents: Jangseong High School Study. 
 Dong Phil Choi  ;  Joo Young Lee  ;  Vogue Ahn  ;  Hyeon Chang Kim 
 Journal of the Korean Society of Hypertension, Vol.18(1) : 29-37, 2012 
Journal Title
 Journal of the Korean Society of Hypertension 
Issue Date
BACKGROUND: Wide pulse pressure associates with atherosclerosis, but it is unclear whether pulse pressure within a relatively normal range is associated with atherosclerosis in younger populations. The aim of this study was to investigate the association between pulse pressure and the carotid intima-media thickness (IMT) in healthy adolescents. METHODS: Study participants included 250 (129 males and 121 females) adolescents who were 17 to 19 years old and in the third grade of a high school in Jangseong, Korea between November 20 and December 1, 2009. Pulse pressure was determined as the difference between systolic blood pressure and diastolic blood pressure which were measured with an oscillometric sphygmomanometer. IMT values were ultrasonographically measured at right and left common carotid arteries, and average of the mean IMT at each artery was used for analysis. RESULTS: There was a significant correlation between pulse pressure and carotid IMT before (Pearson coefficient r = 0.2037, p = 0.001) and after (r = 0.1479, p = 0.020) adjustment for sex. When adjusted for sex, age, waist circumference, fasting blood glucose, and total/high-density lipoprotein cholesterol ratio, 10 mm Hg increase in pulse pressure was associated with increase of IMT in total (beta = 10.9 microm, p = 0.003), in males (beta = 17.3 microm, p < 0.001), but not in females (beta = 3.609 microm, p = 0.518). CONCLUSIONS: This study suggests that higher pulse pressure may be associated with increased carotid IMT even in healthy male adolescents.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
Yonsei Authors
김현창(Kim, Hyeon Chang) ORCID logo https://orcid.org/0000-0001-7867-1240
이주영(Lee, Joo Young)
최동필(Choi, Dong Phil)
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