186 403

Cited 0 times in

Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author이순하-
dc.contributor.author강혜영-
dc.contributor.author한승혁-
dc.contributor.author곽승재-
dc.contributor.author김도희-
dc.contributor.author김좌경-
dc.contributor.author남보영-
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.date.accessioned2014-12-19T17:50:03Z-
dc.date.available2014-12-19T17:50:03Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92145-
dc.description.abstractPURPOSE: This study was undertaken to investigate the effects of gamma linolenic acid (GLA) on inflammation and extracellular matrix (ECM) synthesis in mesangial and tubular epithelial cells under diabetic conditions. MATERIALS AND METHODS: Sprague-Dawley rats were intraperitoneally injected with either a diluent [n=16, control (C)] or streptozotocin [n=16, diabetes (DM)], and eight rats each from the control and diabetic groups were treated with evening primrose oil by gavage for three months. Rat mesangial cells and NRK-52E cells were exposed to medium containing 5.6 mM glucose and 30 mM glucose (HG), with or without GLA (10 or 100 μM). Intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), and fibronectin (FN) mRNA and protein expression levels were evaluated. RESULTS: Twenty-four-hour urinary albumin excretion was significantly increased in DM compared to C rats, and GLA treatment significantly reduced albuminuria in DM rats. ICAM-1, MCP-1, FN mRNA and protein expression levels were significantly higher in DM than in C kidneys, and these increases were significantly abrogated by GLA treatment. In vitro, GLA significantly inhibited increases in MCP-1 mRNA expression and protein levels under high glucose conditions in HG-stimulated mesangial and tubular epithelial cells (p<0.05, respectively). ICAM-1 and FN expression showed a similar pattern to the expression of MCP-1. CONCLUSION: GLA attenuates not only inflammation by inhibiting enhanced MCP-1 and ICAM-1 expression, but also ECM accumulation in diabetic nephropathy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAnti-Inflammatory Agents/therapeutic use*-
dc.subject.MESHBlotting, Western-
dc.subject.MESHChemokine CCL2/genetics-
dc.subject.MESHChemokine CCL2/metabolism-
dc.subject.MESHDiabetic Nephropathies/drug therapy*-
dc.subject.MESHDiabetic Nephropathies/metabolism*-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFibronectins/genetics-
dc.subject.MESHFibronectins/metabolism-
dc.subject.MESHIntercellular Adhesion Molecule-1/genetics-
dc.subject.MESHIntercellular Adhesion Molecule-1/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.subject.MESHalpha-Linolenic Acid/therapeutic use*-
dc.titleGamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorDo-Hee Kim-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorSoon Ha Lee-
dc.contributor.googleauthorHye Young Kang-
dc.contributor.googleauthorBo Young Nam-
dc.contributor.googleauthorSeung Jae Kwak-
dc.contributor.googleauthorJwa-Kyung Kim-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi23074118-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA02908-
dc.contributor.localIdA00096-
dc.contributor.localIdA04304-
dc.contributor.localIdA00170-
dc.contributor.localIdA00931-
dc.contributor.localIdA01251-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA00395-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23074118-
dc.subject.keywordGamma linolenic acid-
dc.subject.keywordexperimental diabetic nephropathy-
dc.subject.keywordanti-inflammatory-
dc.subject.keywordanti-fibrotic-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameLee, Sun Ha-
dc.contributor.alternativeNameKang, Hye Young-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKwak, Seung Jae-
dc.contributor.alternativeNameKim, Do Hee-
dc.contributor.alternativeNameKim, Jwa Kyung-
dc.contributor.alternativeNameNam, Bo Young-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorLee, Sun Ha-
dc.contributor.affiliatedAuthorKang, Hye Young-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKwak, Seung Jae-
dc.contributor.affiliatedAuthorKim, Jwa Kyung-
dc.contributor.affiliatedAuthorNam, Bo Young-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorKim, Do Hee-
dc.citation.volume53-
dc.citation.number6-
dc.citation.startPage1165-
dc.citation.endPage1175-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(6) : 1165-1175, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.