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Myeloperoxidase expression in acute myeloid leukemia helps identifying patients to benefit from transplant

 Yundeok Kim  ;  Sulhee Yoon  ;  Soo Jeong Kim  ;  Jin Seok Kim  ;  Jun-Won Cheong  ;  Yoo Hong Min 
 YONSEI MEDICAL JOURNAL, Vol.53(3) : 530-536, 2012 
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Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cytarabine/therapeutic use ; Disease-Free Survival ; Female ; Flow Cytometry ; Hematopoietic Stem Cell Transplantation ; Humans ; Idarubicin/therapeutic use ; Immunophenotyping ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/enzymology* ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy* ; Male ; Middle Aged ; Peroxidase/metabolism* ; Retrospective Studies ; Young Adult
Myeloperoxidase ; acute myeloid leukemia ; prognostic factor ; transplant
PURPOSE: Despite extensive study, the use of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia (AML) vary considerably. The decision of which of these options to choose is complex and depends on both clinical and molecular variables as well as the availability and histocompatability of donor stem cells. So far there is no clear explanation on whether the expression of myeloperoxidase (MPO) relates to the prognosis of AML. MATERIALS AND METHODS: We retrospectively analyzed the prognostic significance of the MPO expression in the 140 patients with diagnosed AML treated at a single institution. RESULTS: In our study, MPO expression was associated with disease-free survival (DFS) and transplant was beneficial to overcome a negative prognostic effect of MPO-negative at diagnosis based upon the result that the DFS in patients received transplants are not significant between the MPO-positive group and MPO-negative group although DFS in all patients was different according to MPO expression. CONCLUSION: MPO expression at diagnosis helps to choose therapy for each AML patient and can differentiate AML patients who need transplantation.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Kim, Yun Deok(김윤덕) ORCID logo https://orcid.org/0000-0002-5336-7936
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Yoon, Sul Hee(윤설희)
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
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