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Treatment outcome of patients with anaplastic thyroid cancer: a single center experience

Authors
 Sun Min Lim  ;  Sang-Joon Shin  ;  Woong Youn Chung  ;  Cheong Soo Park  ;  Kee-Hyun Nam  ;  Sang-Wook Kang  ;  Ki Chang Keum  ;  Joo Hang Kim  ;  Jae Yong Cho  ;  Yun Kyoung Hong  ;  Byoung Chul Cho 
Citation
 Yonsei Medical Journal, Vol.53(2) : 352-357, 2012 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2012
Abstract
PURPOSE: Anaplastic thyroid cancer is known to have a poor prognosis due to its aggressive and rapid metastasis with median survival of less than 6 months. Multimodal treatment involving surgery and chemoradiotherapy has been used to improve the survival of patients. Here, we retrospectively review of treatment outcome of 13 consecutive patients who were treated at a single center. MATERIALS AND METHODS: We retrospectively reviewed medical records of 13 anaplastic thyroid cancer patients who received multidisciplinary treatment between 2006 and 2010. Kaplan-Meier survival curve was used to analyze progression-free survival and overall survival of patients. RESULTS: The median patient age at diagnosis was 69 years, and six patients had stage IVc diseases. Eight patients received primary surgery followed by radiotherapy or concurrent chemoradiotherapy (CCRT). Five patients received weekly doxorubicin-based definitive CCRT, but only one patient's condition remained stable, while the rest experienced rapid disease progression. The median progression-free survival was 2.8 months (95% CI, 1.2-4.4 months), and the median overall survival was 3.8 months (95% CI, 3.0-4.6 months). CONCLUSION: Patients with anaplastic thyroid cancer showed poor prognosis despite multimodality treatment. Therefore, identification of novel therapeutic targets is warranted to take an effective mode of treatment.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92134
Files in This Item:
T201203218.pdf Download
DOI
10.3349/ymj.2012.53.2.352
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
Yonsei Authors
강상욱(Kang, Sang Wook) ORCID logo https://orcid.org/0000-0001-5355-833X
금기창(Keum, Ki Chang)
김주항(Kim, Joo Hang)
남기현(Nam, Kee Hyun) ORCID logo https://orcid.org/0000-0002-6852-1190
박정수(Park, Cheong Soo)
신상준(Shin, Sang Joon)
임선민(Lim, Sun Min)
정웅윤(Chung, Woung Youn)
조병철(Cho, Byoung Chul)
조재용(Cho, Jae Yong) ORCID logo https://orcid.org/0000-0002-0926-1819
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