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Treatment outcome of patients with anaplastic thyroid cancer: a single center experience
DC Field | Value | Language |
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dc.contributor.author | 박정수 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 정웅윤 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 조재용 | - |
dc.contributor.author | 강상욱 | - |
dc.contributor.author | 금기창 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 남기현 | - |
dc.date.accessioned | 2014-12-19T17:49:42Z | - |
dc.date.available | 2014-12-19T17:49:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92134 | - |
dc.description.abstract | PURPOSE: Anaplastic thyroid cancer is known to have a poor prognosis due to its aggressive and rapid metastasis with median survival of less than 6 months. Multimodal treatment involving surgery and chemoradiotherapy has been used to improve the survival of patients. Here, we retrospectively review of treatment outcome of 13 consecutive patients who were treated at a single center. MATERIALS AND METHODS: We retrospectively reviewed medical records of 13 anaplastic thyroid cancer patients who received multidisciplinary treatment between 2006 and 2010. Kaplan-Meier survival curve was used to analyze progression-free survival and overall survival of patients. RESULTS: The median patient age at diagnosis was 69 years, and six patients had stage IVc diseases. Eight patients received primary surgery followed by radiotherapy or concurrent chemoradiotherapy (CCRT). Five patients received weekly doxorubicin-based definitive CCRT, but only one patient's condition remained stable, while the rest experienced rapid disease progression. The median progression-free survival was 2.8 months (95% CI, 1.2-4.4 months), and the median overall survival was 3.8 months (95% CI, 3.0-4.6 months). CONCLUSION: Patients with anaplastic thyroid cancer showed poor prognosis despite multimodality treatment. Therefore, identification of novel therapeutic targets is warranted to take an effective mode of treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 352~357 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Doxorubicin/therapeutic use | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Thyroid Carcinoma, Anaplastic | - |
dc.subject.MESH | Thyroid Neoplasms/drug therapy* | - |
dc.subject.MESH | Thyroid Neoplasms/mortality | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Treatment outcome of patients with anaplastic thyroid cancer: a single center experience | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Sang-Joon Shin | - |
dc.contributor.googleauthor | Woong Youn Chung | - |
dc.contributor.googleauthor | Cheong Soo Park | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.contributor.googleauthor | Sang-Wook Kang | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Jae Yong Cho | - |
dc.contributor.googleauthor | Yun Kyoung Hong | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.identifier.doi | 22318823 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A03674 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A03899 | - |
dc.contributor.localId | A00032 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01245 | - |
dc.contributor.localId | A01646 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 22318823 | - |
dc.subject.keyword | Anaplastic thyroid cancer | - |
dc.subject.keyword | treatment outcome | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | survival | - |
dc.subject.keyword | chemoradiotherapy | - |
dc.contributor.alternativeName | Park, Cheong Soo | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Lim, Sun Min | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Cho, Jae Yong | - |
dc.contributor.alternativeName | Kang, Sang Wook | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Nam, Kee Hyun | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Lim, Sun Min | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Cho, Jae Yong | - |
dc.contributor.affiliatedAuthor | Kang, Sang Wook | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Nam, Kee Hyun | - |
dc.contributor.affiliatedAuthor | Park, Cheong Soo | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 352 | - |
dc.citation.endPage | 357 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.53(2) : 352-357, 2012 | - |
dc.identifier.rimsid | 29637 | - |
dc.type.rims | ART | - |
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