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Is it suitable to eliminate bone scan for prostate cancer patients with PSA ≤ 20 ng/mL?

 Seung Hwan Lee  ;  Mun Su Chung  ;  Kyung Kgi Park  ;  Chan Dong Yom  ;  Dae Hoon Lee  ;  Byung Ha Chung 
 World Journal of Urology, Vol.30(2) : 265-269, 2012 
Journal Title
 World Journal of Urology 
Issue Date
PURPOSE: We evaluated the relationship between bone metastasis (BM) and clinical or pathological variables, including the serum prostate-specific antigen (PSA) concentration. METHODS: This retrospective study included 579 consecutive patients with newly diagnosed prostate cancer (Pca) who underwent a bone scan study at our institution between 2002 and 2010. We used receiver operating characteristics curves to evaluate accuracy of bone metastasis between serum PSA 10 and 20 ng/mL. RESULTS: A positive bone scan result was found in 83 men (14.3%) with PCa. However, 27 men (4.6%) with serum PSA between 10 and 20 ng/mL, 29/579 men (5.0%) with GS ≤ 7, and 21/83 (25.3%) with serum PSA ≤ 20 ng/mL and Gleason score (GS) ≤ 7 had positive bone scans. In the logistic regression analyses, clinical T stage (odds ratio [OR] = 3.26; 95% CI, 2.29-4.33; P = 0.021), GS (OR = 3.41; 95% CI, 2.91-4.63; P = 0.019), and serum PSA (OR = 8.37; 95% CI, 3.91-19.21; P < 0.001) were predictive factors of detecting the BM. When the serum PSA concentration ≤20 ng/mL and GS ≤ 7, AUC value of bone scans for the detection of BM was 0.640 (P = 0.020; 95% CI, 0.563-0.717). With serum PSA at 10 ng/mL and GS ≤ 7, the AUC values of bone scans were 0.828 (P < 0.001; 95% CI, 0.773-0.883). CONCLUSIONS: Bone scans might be necessary in men with serum PSA between 10 and 20 ng/mL. New guidelines for eliminating bone scans in patients with newly diagnosed Pca are needed, especially in Asians.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
Yonsei Authors
박경기(Park, Kyung Kgi)
이승환(Lee, Seung Hwan) ORCID logo https://orcid.org/0000-0001-7358-8544
정문수(Chung, Mun Su)
정병하(Chung, Byung Ha) ORCID logo https://orcid.org/0000-0001-9817-3660
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