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Is it suitable to eliminate bone scan for prostate cancer patients with PSA ≤ 20 ng/mL?

DC Field Value Language
dc.contributor.author박경기-
dc.contributor.author이승환-
dc.contributor.author정문수-
dc.contributor.author정병하-
dc.date.accessioned2014-12-19T17:46:45Z-
dc.date.available2014-12-19T17:46:45Z-
dc.date.issued2012-
dc.identifier.issn0724-4983-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92041-
dc.description.abstractPURPOSE: We evaluated the relationship between bone metastasis (BM) and clinical or pathological variables, including the serum prostate-specific antigen (PSA) concentration. METHODS: This retrospective study included 579 consecutive patients with newly diagnosed prostate cancer (Pca) who underwent a bone scan study at our institution between 2002 and 2010. We used receiver operating characteristics curves to evaluate accuracy of bone metastasis between serum PSA 10 and 20 ng/mL. RESULTS: A positive bone scan result was found in 83 men (14.3%) with PCa. However, 27 men (4.6%) with serum PSA between 10 and 20 ng/mL, 29/579 men (5.0%) with GS ≤ 7, and 21/83 (25.3%) with serum PSA ≤ 20 ng/mL and Gleason score (GS) ≤ 7 had positive bone scans. In the logistic regression analyses, clinical T stage (odds ratio [OR] = 3.26; 95% CI, 2.29-4.33; P = 0.021), GS (OR = 3.41; 95% CI, 2.91-4.63; P = 0.019), and serum PSA (OR = 8.37; 95% CI, 3.91-19.21; P < 0.001) were predictive factors of detecting the BM. When the serum PSA concentration ≤20 ng/mL and GS ≤ 7, AUC value of bone scans for the detection of BM was 0.640 (P = 0.020; 95% CI, 0.563-0.717). With serum PSA at 10 ng/mL and GS ≤ 7, the AUC values of bone scans were 0.828 (P < 0.001; 95% CI, 0.773-0.883). CONCLUSIONS: Bone scans might be necessary in men with serum PSA between 10 and 20 ng/mL. New guidelines for eliminating bone scans in patients with newly diagnosed Pca are needed, especially in Asians.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfWORLD JOURNAL OF UROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/blood-
dc.subject.MESHAdenocarcinoma/pathology*-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBone Neoplasms/blood-
dc.subject.MESHBone Neoplasms/diagnostic imaging-
dc.subject.MESHBone Neoplasms/secondary*-
dc.subject.MESHBone and Bones/diagnostic imaging*-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHProstate-Specific Antigen/blood*-
dc.subject.MESHProstatic Neoplasms/blood-
dc.subject.MESHProstatic Neoplasms/pathology*-
dc.subject.MESHRadionuclide Imaging-
dc.subject.MESHRetrospective Studies-
dc.titleIs it suitable to eliminate bone scan for prostate cancer patients with PSA ≤ 20 ng/mL?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorMun Su Chung-
dc.contributor.googleauthorKyung Kgi Park-
dc.contributor.googleauthorChan Dong Yom-
dc.contributor.googleauthorDae Hoon Lee-
dc.contributor.googleauthorByung Ha Chung-
dc.identifier.doi21779835-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02938-
dc.contributor.localIdA01419-
dc.contributor.localIdA03601-
dc.contributor.localIdA03607-
dc.relation.journalcodeJ02805-
dc.identifier.eissn1433-8726-
dc.identifier.pmid21779835-
dc.subject.keywordBone scan-
dc.subject.keywordProstate cancer-
dc.subject.keywordProstate-
dc.subject.keywordBone metastasis-
dc.subject.keywordPSA-
dc.contributor.alternativeNamePark, Kyung Kgi-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.alternativeNameChung, Mun Su-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.affiliatedAuthorLee, Seung Hwan-
dc.contributor.affiliatedAuthorPark, Kyung Kgi-
dc.contributor.affiliatedAuthorChung, Mun Su-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.citation.volume30-
dc.citation.number2-
dc.citation.startPage265-
dc.citation.endPage269-
dc.identifier.bibliographicCitationWORLD JOURNAL OF UROLOGY, Vol.30(2) : 265-269, 2012-
dc.identifier.rimsid30088-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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