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Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia

 Hyun Chul Lim  ;  Sang In Lee  ;  Jiande DZ Chen  ;  Hyojin Park 
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.18(41) : 5948-5956, 2012 
Journal Title
Issue Date
Adult ; Aged ; Benzamides/therapeutic use ; Benzyl Compounds/therapeutic use ; Dyspepsia/diagnosis ; Dyspepsia/drug therapy* ; Dyspepsia/physiopathology ; Electrodiagnosis/methods* ; Female ; Gastrointestinal Agents/therapeutic use* ; Humans ; Male ; Middle Aged ; Morpholines/therapeutic use ; Myoelectric Complex, Migrating/drug effects* ; Predictive Value of Tests ; Prospective Studies ; Republic of Korea ; Stomach/drug effects* ; Stomach/physiopathology ; Sulpiride/analogs & derivatives ; Sulpiride/therapeutic use ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome ; Young Adult
Electrogastrography ; Functional dyspepsia ; Itopride ; Levosulpiride ; Mosapride
AIM: To evaluate the effect of prokinetic drugs on electrogastrography (EGG) parameters according to symptomatic changes in patients with functional dyspepsia (FD). METHODS: Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December 2010. We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment. We also measured cutaneous pre-prandial and post-prandial EGG recordings including percentage of gastric waves (normogastria, bradygastria, tachygastria), dominant frequency (DF), dominant power (DP), dominant frequency instability coefficient (DFIC), dominant power instability coefficient (DPIC), and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment. RESULTS: Fifty-two patients (70%) achieved symptomatic improvement after prokinetic drug treatment. Patients who had normal gastric slow waves showed symptom improvement group after treatment. Post-prandial DF showed a downward trend in the symptom improvement group, especially in the itopride group. Post-prandial DP was increased regardless of symptom improvement, especially in the itopride group and mosapride group. Post-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the treatment. The EGG power ratio was increased after treatment in the symptom improvement group (0.50 ± 0.70 vs 0.93 ± 1.77, P = 0.002), especially in the itopride and levosulpiride groups. CONCLUSION: Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity, and EGG could be a useful tool in evaluating the effects of various prokinetics.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Sang In(이상인)
Lim, Hyun Chul(임현철)
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