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Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia

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dc.contributor.author임현철-
dc.contributor.author박효진-
dc.contributor.author이상인-
dc.date.accessioned2014-12-19T17:46:17Z-
dc.date.available2014-12-19T17:46:17Z-
dc.date.issued2012-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92026-
dc.description.abstractAIM: To evaluate the effect of prokinetic drugs on electrogastrography (EGG) parameters according to symptomatic changes in patients with functional dyspepsia (FD). METHODS: Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December 2010. We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment. We also measured cutaneous pre-prandial and post-prandial EGG recordings including percentage of gastric waves (normogastria, bradygastria, tachygastria), dominant frequency (DF), dominant power (DP), dominant frequency instability coefficient (DFIC), dominant power instability coefficient (DPIC), and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment. RESULTS: Fifty-two patients (70%) achieved symptomatic improvement after prokinetic drug treatment. Patients who had normal gastric slow waves showed symptom improvement group after treatment. Post-prandial DF showed a downward trend in the symptom improvement group, especially in the itopride group. Post-prandial DP was increased regardless of symptom improvement, especially in the itopride group and mosapride group. Post-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the treatment. The EGG power ratio was increased after treatment in the symptom improvement group (0.50 ± 0.70 vs 0.93 ± 1.77, P = 0.002), especially in the itopride and levosulpiride groups. CONCLUSION: Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity, and EGG could be a useful tool in evaluating the effects of various prokinetics.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBenzamides/therapeutic use-
dc.subject.MESHBenzyl Compounds/therapeutic use-
dc.subject.MESHDyspepsia/diagnosis-
dc.subject.MESHDyspepsia/drug therapy*-
dc.subject.MESHDyspepsia/physiopathology-
dc.subject.MESHElectrodiagnosis/methods*-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Agents/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMorpholines/therapeutic use-
dc.subject.MESHMyoelectric Complex, Migrating/drug effects*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHStomach/drug effects*-
dc.subject.MESHStomach/physiopathology-
dc.subject.MESHSulpiride/analogs & derivatives-
dc.subject.MESHSulpiride/therapeutic use-
dc.subject.MESHSurveys and Questionnaires-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleElectrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyun Chul Lim-
dc.contributor.googleauthorSang In Lee-
dc.contributor.googleauthorJiande DZ Chen-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi23139612-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03418-
dc.contributor.localIdA01774-
dc.contributor.localIdA02828-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid23139612-
dc.subject.keywordElectrogastrography-
dc.subject.keywordFunctional dyspepsia-
dc.subject.keywordItopride-
dc.subject.keywordLevosulpiride-
dc.subject.keywordMosapride-
dc.contributor.alternativeNameLim, Hyun Chul-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameLee, Sang In-
dc.contributor.affiliatedAuthorLim, Hyun Chul-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorLee, Sang In-
dc.citation.volume18-
dc.citation.number41-
dc.citation.startPage5948-
dc.citation.endPage5956-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.18(41) : 5948-5956, 2012-
dc.identifier.rimsid30079-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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