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Sarcoidosis Presenting with Massive Pleural Effusion and Elevated Serum and Pleural Fluid Carbohydrate Antigen-125 Levels

 Lee In Seon  ;  Kim Sae Byul  ;  Park Moo Suk  ;  Chang Joon  ;  Kim Se Kyu  ;  Kim Young Sam  ;  Kang Young Ae  ;  Jung Ji Ye  ;  Kim Eun Young  ;  Kim Song Yee  ;  Jung Sung Mo  ;  Moon Chan Soo 
 Tuberculosis and Respiratory Diseases, Vol.73(6) : 320-324, 2012 
Journal Title
 Tuberculosis and Respiratory Diseases 
Issue Date
A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae) ; 김샛별(Kim, Sae Byol) ; 김세규(Kim, Se Kyu) ; 김송이(Kim, Song Yi) ; 김영삼(Kim, Young Sam) ; 김은영(Kim, Eun Young) ; 문찬수(Moon, Chan Soo) ; 박무석(Park, Moo Suk) ; 이인선(Lee, In Sun) ; 장준(Chang, Joon) ; 정성모(Jung, Sung Mo) ; 정지예(Jung, Ji Ye)
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