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Sarcoidosis Presenting with Massive Pleural Effusion and Elevated Serum and Pleural Fluid Carbohydrate Antigen-125 Levels

 Lee In Seon  ;  Kim Sae Byul  ;  Moon Chan Soo  ;  Jung Sung Mo  ;  Kim Song Yee  ;  Kim Eun Young  ;  Jung Ji Ye  ;  Kang Young Ae  ;  Kim Young Sam  ;  Kim Se Kyu  ;  Chang Joon  ;  Park Moo Suk 
 Tuberculosis and Respiratory Diseases, Vol.73(6) : 320-324, 2012 
Journal Title
 Tuberculosis and Respiratory Diseases 
Issue Date
A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae)
김샛별(Kim, Sae Byol)
김세규(Kim, Se Kyu)
김송이(Kim, Song Yee)
김영삼(Kim, Young Sam)
김은영(Kim, Eun Young)
문찬수(Moon, Chan Soo)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
이인선(Lee, In Sun)
장준(Chang, Joon)
정성모(Jung, Sung Mo)
정지예(Jung, Ji Ye) ORCID logo https://orcid.org/0000-0003-1589-4142
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