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Sarcoidosis Presenting with Massive Pleural Effusion and Elevated Serum and Pleural Fluid Carbohydrate Antigen-125 Levels

Authors
 Lee In Seon  ;  Kim Sae Byul  ;  Moon Chan Soo  ;  Jung Sung Mo  ;  Kim Song Yee  ;  Kim Eun Young  ;  Jung Ji Ye  ;  Kang Young Ae  ;  Kim Young Sam  ;  Kim Se Kyu  ;  Chang Joon  ;  Park Moo Suk 
Citation
 TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.73(6) : 320-324, 2012 
Journal Title
 TUBERCULOSIS AND RESPIRATORY DISEASES 
ISSN
 1738-3536 
Issue Date
2012
Keywords
Sarcoidosis ; Pleural Effusion ; CA-125 Antigen
Abstract
A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized.
Files in This Item:
T201205653.pdf Download
DOI
10.4046/trd.2012.73.6.320
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Sae Byol(김샛별)
Kim, Se Kyu(김세규)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Young(김은영) ORCID logo https://orcid.org/0000-0002-3281-5744
Moon, Chan Soo(문찬수)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Lee, In Sun(이인선)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Sung Mo(정성모)
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91986
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