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Difference of regeneration potential between healthy and diseased liver

Authors
 M.K. Ju  ;  G.H. Choi  ;  J.S. Park  ;  D.S. Yoon  ;  J. Choi  ;  M.S. Kim  ;  S.I. Kim 
Citation
 Transplantation Proceedings, Vol.44(2) : 338-340, 2012 
Journal Title
 Transplantation Proceedings 
ISSN
 0041-1345 
Issue Date
2012
Abstract
BACKGROUND: We sought to evaluate total and segmental liver regeneration by comparing preoperative computed tomographic (CT) volumetry and CT volumetry on postoperative day (POD) 7 after a right hepatectomy, in patients with various status and surgical indications. METHOD: We included 36 patients who underwent right lobectomy for living donor liver transplantation (healthy group), and 29 for hepatocellular carcinoma treatment (disease group). All of the disease group patients were Child-Turcotte-Pugh (CTP) class A. The regeneration of lateral, medial segment and total remnant liver volumes were assessed on POD 7 using a CT-based program. Total volumes and segmental volumes were measured for total liver, future liver remnant (FLR), and liver remnant. We calculated total and segmental early regeneration indexes, defined as [(VLR-VFLR)/VFLR]×100, where VLR is volume of the liver remnant and VFLR is volume of the FLR. RESULT: The VLR at POD 7 showed a 72.9% increase in volume among the healthy versus 55% in the disease group, (P=.012) In the disease group, segmental volume and regeneration indexes were also significantly lower than among the healthy group: 59.0% versus 46.9% in the medial and 86.8% versus 57.7% in the lateral segment (P=.023 and P<.001) respectively. CONCLUSION: The volume regeneration potential in diseased livers is significantly lower than that of a normal, healthy liver. So, we must consider a patient's liver status and volume profile before an extensive liver.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91965
DOI
10.1016/j.transproceed.2012.01.063
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김명수(Kim, Myoung Soo) ; 김순일(Kim, Soon Il) ; 박준성(Park, Joon Seong) ; 윤동섭(Yoon, Dong Sup) ; 주만기(Joo, Man Ki) ; 최기홍(Choi, Gi Hong) ; 최진섭(Choi, Jin Sub)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0041134512000978
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