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Soluble human leukocyte antigen-G expression in hepatitis B virus infection and hepatocellular carcinoma

 Y. Park  ;  Y. Park  ;  H. S. Lim  ;  Y. S. Kim  ;  D. J. Hong  ;  H. S. Kim 
 TISSUE ANTIGENS , Vol.79(2) : 97-103, 2012 
Journal Title
Issue Date
Adult ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Area Under Curve ; Biomarkers/blood ; Carcinoma, Hepatocellular/blood* ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/virology ; Carrier State ; Case-Control Studies ; DNA, Viral/analysis ; Female ; HLA-G Antigens/blood* ; HLA-G Antigens/immunology ; Hepatitis B virus/immunology* ; Hepatitis B, Chronic/blood* ; Hepatitis B, Chronic/immunology ; Hepatitis B, Chronic/virology ; Humans ; Liver Cirrhosis/blood* ; Liver Cirrhosis/immunology ; Liver Cirrhosis/virology ; Liver Neoplasms/blood* ; Liver Neoplasms/immunology ; Liver Neoplasms/virology ; Male ; Middle Aged ; Neoplasm Grading ; Republic of Korea ; Sensitivity and Specificity ; Severity of Illness Index ; Solubility ; Transaminases/blood ; alpha-Fetoproteins/analysis
cancer diagnosis ; hepatitis B virus ; hepatocellular carcinoma ; human leukocyteantigen-G
We investigated soluble human leukocyte antigen-G (sHLA-G) expression according to the phases of hepatitis B virus (HBV) infections and hepatocellular carcinoma (HCC). A total of 267 sera from anti-HBs positive healthy individuals (n = 50), chronic HBV carriers (n = 45), as well as patients with active hepatitis B (n = 46), liver cirrhosis (LC, n = 46) and early stage HCC (n = 80) were collected and assayed for sHLA-G. Relationships between sHLA-G levels and clinicopathologic parameters including HCC stages, differentiation grades, and levels of aminotransferases, HBV DNA and alpha-fetoprotein (AFP) were assessed. Concentrations of sHLA-G were higher in the active hepatitis B and HCC groups (median sHLA-G 53.7 and 178.8 U/ml, respectively) in comparison to other groups (P < 0.05), and there were no significant differences among sHLA-G levels of the anti-HBs positive, chronic HBV carrier and LC groups. Serum sHLA-G concentrations were not shown to be associated with clinicopathologic indices including the levels of aminotransferases, AFP, anti-HBs titer, HBV DNA, as well as HCC stages, numbers of tumor nodules, pathologic grades and presence of vessel invasion. The receiver-operating characteristic area under the curve (AUC) value of sHLA-G for differentiating HCC from LC was 0.98, which was greater than that of AFP (0.78) (P < 0.0001), and sensitivity and specificity of sHLA-G were, respectively, 90.0% and 95.7% for HCC when applying a cutoff level of 97.3 U/ml. Serum sHLA-G levels could be used as a diagnostic marker for HCC. Although sHLA-G levels did not reflect the severity of HBV infections and HCC, they were related with phases of the disease.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Yong Jung(박용정)
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