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Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer

Authors
 Sang Joon Shin  ;  Joong Bae Ahn  ;  Jin Sub Choi  ;  Gi-Hong Choi  ;  Kang Young Lee  ;  Seung Hyuk Baik  ;  Byung Soh Min  ;  Hyuk Hur  ;  Jae Kyung Roh  ;  Nam Kyu Kim 
Citation
 SURGICAL ONCOLOGY-OXFORD, Vol.21(3) : 125-130, 2012 
Journal Title
 SURGICAL ONCOLOGY-OXFORD 
ISSN
 0960-7404 
Issue Date
2012
MeSH
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Catheter Ablation/methods ; Catheter Ablation/mortality ; Colorectal Neoplasms* ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/secondary* ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoadjuvant Therapy/mortality ; Neoplasm Recurrence, Local/mortality ; Prospective Studies ; Retrospective Studies ; Risk Assessment ; Treatment Outcome ; Young Adult
Keywords
Colorectal cancer ; Liver metastasis ; Clinical risk score ; Treatment decision ; Multidisciplinary
Abstract
OBJECTIVE/BACKGROUND: We investigated the usefulness of a clinical risk scoring system (CRS) for guiding management and defining prognosis for patients with colorectal liver met"astases (CLM). METHOD: We retrospectively analyzed data about the correlation between outcomes and Fong's CRS from 1989 to 2010 for patients treated for CLM at the Severance Hospital. RESULTS: Of 566 patients, 232 received adjuvant treatment after liver resection. Of these patients, 185 (81%) had a low CRS (0-2) and 47 (19%) had a high CRS (3-5). Stratification into high and low CRS allowed significant distinction between Kaplan-Meier curves for outcome. The 5-year survival rate was 88.5% and 11.5% among patients with a low and high CRS, respectively (P < 0.001). Seventy patients with initially unresectable CLM underwent liver resection after tumor downsizing by induction chemotherapy. Shifting of the CRS from high to low (8 patients; 11.4%) improved disease-free survival and overall survival. CONCLUSION: High CRS is associated with worse survival after resection in resectable and unresectable disease. The CRS may be used for risk assessment when recommending oncological surgical timing in initially unresectable disease and treatment options for perioperative or adjuvant treatment in resectable disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0960740412000254
DOI
22560405
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Roh, Jae Kyung(노재경)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Lee, Kang Young(이강영)
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Sub(최진섭)
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91910
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