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Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer

Authors
 Sang Joon Shin ; Joong Bae Ahn ; Nam Kyu Kim ; Jae Kyung Roh ; Hyuk Hur ; Byung Soh Min ; Seung Hyuk Baik ; Kang Young Lee ; Gi-Hong Choi ; Jin Sub Choi 
Citation
 Surgical Oncology, Vol.21(3) : e125~e130, 2012 
Journal Title
 Surgical Oncology 
ISSN
 0960-7404 
Issue Date
2012
Abstract
OBJECTIVE/BACKGROUND: We investigated the usefulness of a clinical risk scoring system (CRS) for guiding management and defining prognosis for patients with colorectal liver met"astases (CLM). METHOD: We retrospectively analyzed data about the correlation between outcomes and Fong's CRS from 1989 to 2010 for patients treated for CLM at the Severance Hospital. RESULTS: Of 566 patients, 232 received adjuvant treatment after liver resection. Of these patients, 185 (81%) had a low CRS (0-2) and 47 (19%) had a high CRS (3-5). Stratification into high and low CRS allowed significant distinction between Kaplan-Meier curves for outcome. The 5-year survival rate was 88.5% and 11.5% among patients with a low and high CRS, respectively (P < 0.001). Seventy patients with initially unresectable CLM underwent liver resection after tumor downsizing by induction chemotherapy. Shifting of the CRS from high to low (8 patients; 11.4%) improved disease-free survival and overall survival. CONCLUSION: High CRS is associated with worse survival after resection in resectable and unresectable disease. The CRS may be used for risk assessment when recommending oncological surgical timing in initially unresectable disease and treatment options for perioperative or adjuvant treatment in resectable disease.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91910
DOI
10.1016/j.suronc.2012.04.002
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0960740412000254
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