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Diagnostic value of the serum galactomannan assay for invasive aspergillosis: it is less useful in non-haematological patients

 Nam Su Ku  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Sun Bean Kim  ;  Hye-Won Kim  ;  Su Jin Jeong  ;  Chang Oh Kim  ;  Young Goo Song  ;  June Myung Kim Read More: http://informahealthcare.com/doi/abs/ . / . . 
 Scandinavian Journal of Infectious Diseases, Vol.44(8) : 600-604, 2012 
Journal Title
 Scandinavian Journal of Infectious Diseases 
Issue Date
BACKGROUND: The serum galactomannan assay (GMA) has been widely used for the diagnosis of invasive aspergillosis (IA). GMA is mainly used in patients with haematological malignancies or in those who have undergone haematopoietic stem cell transplantation (HSCT). However, there are few data from non-haematological patients. We evaluated whether GMA is useful for the diagnosis of IA in non-haematological patients. METHODS: Patients who were subjected to serum GMA testing from January 2007 to December 2009 were evaluated retrospectively. Patients with haematological diseases or who underwent HSCT were excluded from our analysis. According to the criteria of the European Organization for Research and Treatment of Cancer/Mycoses Study Group revised in 2008, the patients were categorized as proven, probable, possible, or non-IA. Proven and probable cases were defined as IA in this study. RESULTS: Out of 778 patients, 13 (1.6%) had proven (n =9) or probable (n =4) IA. The sensitivity of the GMA was 23.1% (95% confidence interval (CI) 6.1-54.0%) and the specificity was 76.1% (95% CI 72.9-79.0%). The positive predictive value was 1.6% (95% CI 0.4-5.0%) and the negative predictive value was 98.3% (95% CI 96.8-99.1%). The likelihood ratios of a positive and negative test were 0.96 (95% CI 0.35-2.62) and 1.01 (95% CI 0.75-1.36), respectively. CONCLUSIONS: In this study, the sensitivity of the GMA for the diagnosis of IA was very low in non-haematological patients. Although the GMA test is considered useful for the diagnosis of IA in haematological patients, it had low diagnostic value for IA in non-haematological patients.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김선빈(Kim, Sun Bean)
김준명(Kim, June Myung)
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
김혜원(Kim, Hye Won)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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