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Diagnostic value of the serum galactomannan assay for invasive aspergillosis: it is less useful in non-haematological patients

Authors
 Nam Su Ku  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Sun Bean Kim  ;  Hye-Won Kim  ;  Su Jin Jeong  ;  Chang Oh Kim  ;  Young Goo Song  ;  June Myung Kim Read More: http://informahealthcare.com/doi/abs/ . / . . 
Citation
 SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, Vol.44(8) : 600-604, 2012 
Journal Title
 SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 
ISSN
 0036-5548 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aspergillosis/blood* ; Aspergillosis/diagnosis ; Female ; Humans ; Immunoenzyme Techniques/methods ; Immunoenzyme Techniques/standards ; Male ; Mannans/blood* ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity
Keywords
Galactomannan assay ; invasive aspergillosis ; non-haematological patients
Abstract
BACKGROUND: The serum galactomannan assay (GMA) has been widely used for the diagnosis of invasive aspergillosis (IA). GMA is mainly used in patients with haematological malignancies or in those who have undergone haematopoietic stem cell transplantation (HSCT). However, there are few data from non-haematological patients. We evaluated whether GMA is useful for the diagnosis of IA in non-haematological patients. METHODS: Patients who were subjected to serum GMA testing from January 2007 to December 2009 were evaluated retrospectively. Patients with haematological diseases or who underwent HSCT were excluded from our analysis. According to the criteria of the European Organization for Research and Treatment of Cancer/Mycoses Study Group revised in 2008, the patients were categorized as proven, probable, possible, or non-IA. Proven and probable cases were defined as IA in this study. RESULTS: Out of 778 patients, 13 (1.6%) had proven (n =9) or probable (n =4) IA. The sensitivity of the GMA was 23.1% (95% confidence interval (CI) 6.1-54.0%) and the specificity was 76.1% (95% CI 72.9-79.0%). The positive predictive value was 1.6% (95% CI 0.4-5.0%) and the negative predictive value was 98.3% (95% CI 96.8-99.1%). The likelihood ratios of a positive and negative test were 0.96 (95% CI 0.35-2.62) and 1.01 (95% CI 0.75-1.36), respectively. CONCLUSIONS: In this study, the sensitivity of the GMA for the diagnosis of IA was very low in non-haematological patients. Although the GMA test is considered useful for the diagnosis of IA in haematological patients, it had low diagnostic value for IA in non-haematological patients.
Full Text
http://informahealthcare.com/doi/abs/10.3109/00365548.2012.657672
DOI
22385270
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Sun Bean(김선빈)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hye Won(김혜원)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91829
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