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Clinical characteristics of acute hepatitis A complicated by acute kidney injury

 Jung Hwan Yu  ;  Ja Kyung Kim  ;  Jun yong Park  ;  Yong Han Paik  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han  ;  Chae Yoon Chon  ;  Kwan Sik Lee 
 Scandinavian Journal of Infectious Diseases, Vol.44(2) : 144-148, 2012 
Journal Title
 Scandinavian Journal of Infectious Diseases 
Issue Date
BACKGROUND: The incidence of acute viral hepatitis A (AHA) in Korea is increasing rapidly. Additionally, we are encountering more cases with acute kidney injury (AKI), which was once regarded as a rare complication of AHA. Thus, we investigated recent aspects of the incidence and clinical characteristics of AHA complicated by AKI. METHODS: Patients diagnosed with AHA at 2 referral hospitals in Seoul during the period January 2006 to December 2009 were enrolled. RESULTS: Of 1025 patients, 71 (6.9%) had AKI. The incidence of AKI was 3.1% in 2006, 6.0% in 2007, 8.9% in 2008, and 6.9% in 2009. Patients with AKI were predominantly male, heavy alcohol drinkers, and smokers, and also had a higher rate of underlying hypertension than patients without AKI. At admission, patients with AKI had significantly higher white blood cell counts, prolonged prothrombin times, and elevated liver enzymes, including total and direct bilirubin, gamma-glutamyltransferase, and C-reactive protein. Additionally, patients with AKI had a higher peak total bilirubin level and lower initial serum albumin level than patients without AKI. CONCLUSION: Although most patients with AHA complicated by AKI recover with conservative treatment, we should pay particular attention to patients who have risk factors for AKI.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김도영(Kim, Do Young) ; 김자경(Kim, Ja Kyung) ; 박준용(Park, Jun Yong) ; 백용한(Paik, Yong Han) ; 안상훈(Ahn, Sang Hoon) ; 유정환(You, Jung Whan) ; 이관식(Lee, Kwan Sik) ; 전재윤(Chon, Chae Yoon) ; 한광협(Han, Kwang Hyup)
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