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Relationship between neural activity and immunity in patients with undifferentiated somatoform disorder

Authors
 Kyung Bong Koh  ;  Seok-Han Sohn  ;  Jee In Kang  ;  Young-joon Lee  ;  Jong Doo Lee 
Citation
 Psychiatry Research-Neuroimaging, Vol.202(3) : 252-256, 2012 
Journal Title
 Psychiatry Research-Neuroimaging 
ISSN
 0925-4927 
Issue Date
2012
Abstract
It has been suggested that somatoform disorders are related to both the brain and the immune system, and that immune functions may be influenced by cerebral asymmetry. However, few studies have examined the relationship between brain activity and immune function in somatoform disorders. Thirty-two patients with non-medicated undifferentiated somatoform disorder were enrolled in this study. Blastogenic responses to phytohemagglutinin (PHA) were used to measure immunity. Regional cerebral perfusion was measured by 99m-Tc-ethyl cysteinate dimer single photon emission computed tomography (SPECT). Significant hypoperfusion was found at the left inferior parietal lobule and the left supramarginal gyrus in the more immune-suppressed (MIS) subgroup compared with the less immune-suppressed (LIS) subgroup. However, no regions of significant hyperperfusion were found in the MIS subgroup compared with the LIS subgroup. Decreased cerebral blood flow in the left inferior parietal lobule and the left supramarginal gyrus in the patient group was also significantly associated with reduced blastogenic responses to PHA regardless of sex and age. These results suggest that the left inferior parietal lobule and the left supramarginal gyrus might play an immunomodulating role in patients with undifferentiated somatoform disorder. In addition, these results suggest the role of cerebral asymmetry in altered immunity in the patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0925492711003817
DOI
10.1016/j.pscychresns.2011.11.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Koh, Kyung Bong(고경봉)
Lee, Youngjoon(이영준) ORCID logo https://orcid.org/0000-0002-9602-5186
Lee, Jong Doo(이종두)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91762
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