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Relationship between neural activity and immunity in patients with undifferentiated somatoform disorder
DC Field | Value | Language |
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dc.contributor.author | 강지인 | - |
dc.contributor.author | 고경봉 | - |
dc.contributor.author | 이영준 | - |
dc.contributor.author | 이종두 | - |
dc.date.accessioned | 2014-12-19T17:37:33Z | - |
dc.date.available | 2014-12-19T17:37:33Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0165-1781 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91762 | - |
dc.description.abstract | It has been suggested that somatoform disorders are related to both the brain and the immune system, and that immune functions may be influenced by cerebral asymmetry. However, few studies have examined the relationship between brain activity and immune function in somatoform disorders. Thirty-two patients with non-medicated undifferentiated somatoform disorder were enrolled in this study. Blastogenic responses to phytohemagglutinin (PHA) were used to measure immunity. Regional cerebral perfusion was measured by 99m-Tc-ethyl cysteinate dimer single photon emission computed tomography (SPECT). Significant hypoperfusion was found at the left inferior parietal lobule and the left supramarginal gyrus in the more immune-suppressed (MIS) subgroup compared with the less immune-suppressed (LIS) subgroup. However, no regions of significant hyperperfusion were found in the MIS subgroup compared with the LIS subgroup. Decreased cerebral blood flow in the left inferior parietal lobule and the left supramarginal gyrus in the patient group was also significantly associated with reduced blastogenic responses to PHA regardless of sex and age. These results suggest that the left inferior parietal lobule and the left supramarginal gyrus might play an immunomodulating role in patients with undifferentiated somatoform disorder. In addition, these results suggest the role of cerebral asymmetry in altered immunity in the patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PSYCHIATRY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Brain/diagnostic imaging | - |
dc.subject.MESH | Brain/pathology* | - |
dc.subject.MESH | Brain Mapping* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Cysteine/analogs & derivatives | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Functional Laterality | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunity/drug effects | - |
dc.subject.MESH | Immunity/physiology* | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Lymphocyte Activation/drug effects | - |
dc.subject.MESH | Lymphocyte Activation/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Organotechnetium Compounds | - |
dc.subject.MESH | Phytohemagglutinins/pharmacology | - |
dc.subject.MESH | Psychometrics | - |
dc.subject.MESH | Somatoform Disorders/diagnostic imaging | - |
dc.subject.MESH | Somatoform Disorders/immunology* | - |
dc.subject.MESH | Somatoform Disorders/pathology* | - |
dc.subject.MESH | Tomography, Emission-Computed, Single-Photon | - |
dc.subject.MESH | Young Adult | - |
dc.title | Relationship between neural activity and immunity in patients with undifferentiated somatoform disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Kyung Bong Koh | - |
dc.contributor.googleauthor | Seok-Han Sohn | - |
dc.contributor.googleauthor | Jee In Kang | - |
dc.contributor.googleauthor | Young-joon Lee | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.identifier.doi | 22801462 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00084 | - |
dc.contributor.localId | A00108 | - |
dc.contributor.localId | A02962 | - |
dc.contributor.localId | A03138 | - |
dc.relation.journalcode | J02571 | - |
dc.identifier.eissn | 1872-7123 | - |
dc.identifier.pmid | 22801462 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0925492711003817 | - |
dc.subject.keyword | Undifferentiated somatoform disorder | - |
dc.subject.keyword | Blastogenic responses to PHA | - |
dc.subject.keyword | Regional cerebral perfusion | - |
dc.subject.keyword | Left inferior parietal lobule | - |
dc.subject.keyword | Left supramarginal gyrus | - |
dc.contributor.alternativeName | Kang, Jee In | - |
dc.contributor.alternativeName | Koh, Kyung Bong | - |
dc.contributor.alternativeName | Lee, Young Joon | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Kang, Jee In | - |
dc.contributor.affiliatedAuthor | Koh, Kyung Bong | - |
dc.contributor.affiliatedAuthor | Lee, Young Joon | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.citation.volume | 202 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 252 | - |
dc.citation.endPage | 256 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY RESEARCH, Vol.202(3) : 252-256, 2012 | - |
dc.identifier.rimsid | 31176 | - |
dc.type.rims | ART | - |
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