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Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration

Authors
 Yoshitaka Murakami  ;  Rachel R. Huxley  ;  Tai-Hing Lam  ;  Rumi Tsukinoki  ;  Xianghua Fang  ;  Hyeon Chang Kim  ;  Mark Woodward 
Citation
 Preventive Medicine, Vol.54(1) : 38-41, 2012 
Journal Title
 Preventive Medicine 
ISSN
 0091-7435 
Issue Date
2012
Abstract
OBJECTIVE: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. METHODS: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24 years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. RESULTS: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p=0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p=0.33), ischemic stroke (p=0.97) and hemorrhagic stroke (p=0.98). CONCLUSIONS: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes.
Full Text
http://www.sciencedirect.com/science/article/pii/S0091743511004282
DOI
10.1016/j.ypmed.2011.10.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91748
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