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The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization

Authors
 Young Seok Park  ;  Young Joo Jeon  ;  Hyun Seok Kim  ;  Kyu Young Chae  ;  Seung-Hun Oh  ;  In Bo Han  ;  Hyun Sook Kim  ;  Won-Chan Kim  ;  Ok-Joon Kim  ;  Tae Gon Kim  ;  Joong-Uhn Choi  ;  Dong-Seok Kim  ;  Nam Keun Kim 
Citation
 PLoS One, Vol.7(10) : e47158, 2012 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2012
Abstract
We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91739
Files in This Item:
T201205234.pdf Download
DOI
10.1371/journal.pone.0047158
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
김동석(Kim, Dong Seok)
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