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The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization
DC Field | Value | Language |
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dc.contributor.author | 김동석 | - |
dc.date.accessioned | 2014-12-19T17:36:51Z | - |
dc.date.available | 2014-12-19T17:36:51Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91739 | - |
dc.description.abstract | We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics | - |
dc.subject.MESH | Carotid Arteries/metabolism | - |
dc.subject.MESH | Carotid Arteries/physiopathology* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Moyamoya Disease/genetics* | - |
dc.subject.MESH | Moyamoya Disease/physiopathology* | - |
dc.subject.MESH | Neovascularization, Physiologic | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/genetics* | - |
dc.subject.MESH | Vascular Endothelial Growth Factor Receptor-2/genetics* | - |
dc.subject.MESH | Young Adult | - |
dc.title | The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Young Seok Park | - |
dc.contributor.googleauthor | Young Joo Jeon | - |
dc.contributor.googleauthor | Hyun Seok Kim | - |
dc.contributor.googleauthor | Kyu Young Chae | - |
dc.contributor.googleauthor | Seung-Hun Oh | - |
dc.contributor.googleauthor | In Bo Han | - |
dc.contributor.googleauthor | Hyun Sook Kim | - |
dc.contributor.googleauthor | Won-Chan Kim | - |
dc.contributor.googleauthor | Ok-Joon Kim | - |
dc.contributor.googleauthor | Tae Gon Kim | - |
dc.contributor.googleauthor | Joong-Uhn Choi | - |
dc.contributor.googleauthor | Dong-Seok Kim | - |
dc.contributor.googleauthor | Nam Keun Kim | - |
dc.identifier.doi | 23077562 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00402 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 23077562 | - |
dc.subject.keyword | Adolescent | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Asian Continental Ancestry Group/genetics | - |
dc.subject.keyword | Carotid Arteries/metabolism | - |
dc.subject.keyword | Carotid Arteries/physiopathology* | - |
dc.subject.keyword | Case-Control Studies | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Child, Preschool | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Haplotypes | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Moyamoya Disease/genetics* | - |
dc.subject.keyword | Moyamoya Disease/physiopathology* | - |
dc.subject.keyword | Neovascularization, Physiologic | - |
dc.subject.keyword | Polymorphism, Single Nucleotide* | - |
dc.subject.keyword | Vascular Endothelial Growth Factor A/genetics* | - |
dc.subject.keyword | Vascular Endothelial Growth Factor Receptor-2/genetics* | - |
dc.subject.keyword | Young Adult | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.citation.volume | 7 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | e47158 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.7(10) : e47158, 2012 | - |
dc.identifier.rimsid | 29584 | - |
dc.type.rims | ART | - |
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