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The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization

DC FieldValueLanguage
dc.contributor.author김동석-
dc.date.accessioned2014-12-19T17:36:51Z-
dc.date.available2014-12-19T17:36:51Z-
dc.date.issued2012-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91739-
dc.description.abstractWe conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHCarotid Arteries/metabolism-
dc.subject.MESHCarotid Arteries/physiopathology*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHaplotypes-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMoyamoya Disease/genetics*-
dc.subject.MESHMoyamoya Disease/physiopathology*-
dc.subject.MESHNeovascularization, Physiologic-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHVascular Endothelial Growth Factor A/genetics*-
dc.subject.MESHVascular Endothelial Growth Factor Receptor-2/genetics*-
dc.subject.MESHYoung Adult-
dc.titleThe role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorYoung Seok Park-
dc.contributor.googleauthorYoung Joo Jeon-
dc.contributor.googleauthorHyun Seok Kim-
dc.contributor.googleauthorKyu Young Chae-
dc.contributor.googleauthorSeung-Hun Oh-
dc.contributor.googleauthorIn Bo Han-
dc.contributor.googleauthorHyun Sook Kim-
dc.contributor.googleauthorWon-Chan Kim-
dc.contributor.googleauthorOk-Joon Kim-
dc.contributor.googleauthorTae Gon Kim-
dc.contributor.googleauthorJoong-Uhn Choi-
dc.contributor.googleauthorDong-Seok Kim-
dc.contributor.googleauthorNam Keun Kim-
dc.identifier.doi23077562-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00402-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid23077562-
dc.subject.keywordAdolescent-
dc.subject.keywordAdult-
dc.subject.keywordAsian Continental Ancestry Group/genetics-
dc.subject.keywordCarotid Arteries/metabolism-
dc.subject.keywordCarotid Arteries/physiopathology*-
dc.subject.keywordCase-Control Studies-
dc.subject.keywordChild-
dc.subject.keywordChild, Preschool-
dc.subject.keywordFemale-
dc.subject.keywordHaplotypes-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMoyamoya Disease/genetics*-
dc.subject.keywordMoyamoya Disease/physiopathology*-
dc.subject.keywordNeovascularization, Physiologic-
dc.subject.keywordPolymorphism, Single Nucleotide*-
dc.subject.keywordVascular Endothelial Growth Factor A/genetics*-
dc.subject.keywordVascular Endothelial Growth Factor Receptor-2/genetics*-
dc.subject.keywordYoung Adult-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.citation.volume7-
dc.citation.number10-
dc.citation.startPagee47158-
dc.identifier.bibliographicCitationPLOS ONE, Vol.7(10) : e47158, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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