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Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with IgA nephropathy

Authors
 Seung Jun Kim  ;  Hyang Mo Koo  ;  Beom Jin Lim  ;  Hyung Jung Oh  ;  Dong Eun Yoo  ;  Dong Ho Shin  ;  Mi Jung Lee  ;  Fa Mee Doh  ;  Jung Tak Park  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Hyeon Joo Jeong  ;  Seung Hyeok Han 
Citation
 PLoS One, Vol.7(7) : e40495, 2012 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2012
Abstract
BACKGROUND AND AIMS: Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of IgAN is uncertain. In this observational cohort study, we aimed to identify the clinical implications of circulating C3 levels and mesangial C3 deposition and to investigate their utility as predictors of renal outcomes in patients with IgAN. METHODS: A total of 343 patients with biopsy-proven IgAN were enrolled between January 2000 and December 2008. Decreased serum C3 level (hypoC3) was defined as C3 <90 mg/dl. The study endpoint was end-stage renal disease (ESRD) and a doubling of the baseline serum creatinine (D-SCr). RESULTS: Of the patients, there were 66 patients (19.2%) with hypoC3. During a mean follow-up of 53.7 months, ESRD occurred in 5 patients (7.6%) with hypoC3 compared with 9 patients (3.2%) with normal C3 levels (P = 0.11). However, 12 patients (18.2%) with hypoC3 reached D-SCr compared with 17 patients (6.1%) with normal C3 levels [Hazard ratio (HR), 3.59; 95% confidence interval (CI), 1.33-10.36; P = 0.018]. In a multivariable model in which serum C3 levels were treated as a continuous variable, hypoC3 significantly predicted renal outcome of D-SCr (per 1 mg/dl increase of C3; HR, 0.95; 95% CI, 0.92-0.99; P = 0.011). The risk of reaching renal outcome was significantly higher in patients with mesangial C3 deposition 2+ to 3+ than in patients without deposition (HR 9.37; 95% CI, 1.10-80.26; P = 0.04). CONCLUSIONS: This study showed that hypoC3 and mesangial C3 deposition were independent risk factors for progression, suggesting that complement activation may play a pathogenic role in patients with IgAN.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91702
DOI
10.1371/journal.pone.0040495
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강신욱(Kang, Shin Wook) ; 구향모(Koo, Hyang Mo) ; 김승준(Kim, Seung Jun) ; 도화미(Doh, Fa Mee) ; 박정탁(Park, Jung Tak) ; 신동호(Shin, Dong Ho) ; 오형중(Oh, Hyung Jung) ; 유동은(Yoo, Dong Eun) ; 유태현(Yoo, Tae Hyun) ; 이미정(Lee, Mi Jung) ; 임범진(Lim, Beom Jin) ; 정현주(Jeong, Hyeon Joo) ; 최규헌(Choi, Kyu Hun) ; 한승혁(Han, Seung Hyeok)
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