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Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with IgA nephropathy

DC FieldValueLanguage
dc.contributor.author도화미-
dc.contributor.author정현주-
dc.contributor.author박정탁-
dc.contributor.author최규헌-
dc.contributor.author한승혁-
dc.contributor.author오형중-
dc.contributor.author유동은-
dc.contributor.author강신욱-
dc.contributor.author유태현-
dc.contributor.author구향모-
dc.contributor.author이미정-
dc.contributor.author김승준-
dc.contributor.author임범진-
dc.date.accessioned2014-12-19T17:35:39Z-
dc.date.available2014-12-19T17:35:39Z-
dc.date.issued2012-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91702-
dc.description.abstractBACKGROUND AND AIMS: Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of IgAN is uncertain. In this observational cohort study, we aimed to identify the clinical implications of circulating C3 levels and mesangial C3 deposition and to investigate their utility as predictors of renal outcomes in patients with IgAN. METHODS: A total of 343 patients with biopsy-proven IgAN were enrolled between January 2000 and December 2008. Decreased serum C3 level (hypoC3) was defined as C3 <90 mg/dl. The study endpoint was end-stage renal disease (ESRD) and a doubling of the baseline serum creatinine (D-SCr). RESULTS: Of the patients, there were 66 patients (19.2%) with hypoC3. During a mean follow-up of 53.7 months, ESRD occurred in 5 patients (7.6%) with hypoC3 compared with 9 patients (3.2%) with normal C3 levels (P = 0.11). However, 12 patients (18.2%) with hypoC3 reached D-SCr compared with 17 patients (6.1%) with normal C3 levels [Hazard ratio (HR), 3.59; 95% confidence interval (CI), 1.33-10.36; P = 0.018]. In a multivariable model in which serum C3 levels were treated as a continuous variable, hypoC3 significantly predicted renal outcome of D-SCr (per 1 mg/dl increase of C3; HR, 0.95; 95% CI, 0.92-0.99; P = 0.011). The risk of reaching renal outcome was significantly higher in patients with mesangial C3 deposition 2+ to 3+ than in patients without deposition (HR 9.37; 95% CI, 1.10-80.26; P = 0.04). CONCLUSIONS: This study showed that hypoC3 and mesangial C3 deposition were independent risk factors for progression, suggesting that complement activation may play a pathogenic role in patients with IgAN.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDecreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with IgA nephropathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorSeung Jun Kim-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorDong Eun Yoo-
dc.contributor.googleauthorDong Ho Shin-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1371/journal.pone.0040495-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01315-
dc.contributor.localIdA03771-
dc.contributor.localIdA01654-
dc.contributor.localIdA04043-
dc.contributor.localIdA02097-
dc.contributor.localIdA04304-
dc.contributor.localIdA02417-
dc.contributor.localIdA02461-
dc.contributor.localIdA00053-
dc.contributor.localIdA02526-
dc.contributor.localIdA00203-
dc.contributor.localIdA03363-
dc.contributor.localIdA00659-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ02540-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Dong Eun-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameKim, Seung Jun-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Dong Eun-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorKim, Seung Jun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.citation.volume7-
dc.citation.number7-
dc.citation.startPagee40495-
dc.identifier.bibliographicCitationPLoS One, Vol.7(7) : e40495, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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