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Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers

DC FieldValueLanguage
dc.contributor.author이덕철-
dc.contributor.author이지연-
dc.contributor.author이지원-
dc.contributor.author이향규-
dc.date.accessioned2014-12-19T17:35:35Z-
dc.date.available2014-12-19T17:35:35Z-
dc.date.issued2012-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91700-
dc.description.abstractBACKGROUND: Carcinoembryonic antigen (CEA) is a tumor marker overexpressed in adenocarcinoma that has proinflammatory properties. Recent studies have reported that CEA is positively associated with carotid atherosclerosis and metabolic syndrome. Because visceral obesity is a known risk factor for cardiometabolic diseases, CEA may also be associated with visceral adiposity. Therefore, we investigated the relationship between serum CEA concentration and visceral obesity in female Korean nonsmokers. METHODS: A total of 270 Korean female nonsmokers were enrolled during their routine health check-ups. Biomarkers of metabolic risk factors were assessed along with body composition by computed tomography. Serum CEA levels were measured by using a chemiluminescence immunoassay analyzer. RESULTS: Serum CEA levels correlated with visceral fat area, fasting glucose, and triglyceride levels after adjusting for age and BMI. The mean visceral fat area increased significantly with the increasing CEA tirtiles. In a step-wise multiple regression analysis, age (β = 0.26, p<0.01) and visceral fat area (β = 0.19, p = 0.03) were identified as explanatory variables for serum CEA level. CONCLUSIONS: This study suggested that CEA may be a mediator that links metabolic disturbance and tumorigenesis in visceral obesity. Further studies are required to better understand the clinical and pathophysiological significance of our findings.-
dc.description.statementOfResponsibilityopen-
dc.format.extente43518-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSerum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers-
dc.typeArticle-
dc.contributor.collegeCollege of Nursing (간호대학)-
dc.contributor.departmentDept. of Nursing Environment Systems (임상간호과학과)-
dc.contributor.googleauthorJee-Yon Lee-
dc.contributor.googleauthorHyang-Kyu Lee-
dc.contributor.googleauthorDuk-Chul Lee-
dc.contributor.googleauthorJi-Won Lee-
dc.identifier.doi10.1371/journal.pone.0043518-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02716-
dc.contributor.localIdA03196-
dc.contributor.localIdA03282-
dc.contributor.localIdA03203-
dc.relation.journalcodeJ02540-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.alternativeNameLee, Jee Yon-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.alternativeNameLee, Hyang Kyu-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.contributor.affiliatedAuthorLee, Jee Yon-
dc.contributor.affiliatedAuthorLee, Hyang Kyu-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.citation.volume7-
dc.citation.number8-
dc.citation.startPagee43518-
dc.identifier.bibliographicCitationPLoS One, Vol.7(8) : e43518, 2012-
dc.description.scptc9-
dc.date.scptcdate2018-12-23-
Appears in Collections:
1. Journal Papers (연구논문) > 3. College of Nursing (간호대학) > Dept. of Nursing (간호학과)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)

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