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Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis

Authors
 Seung Up Kim  ;  Ji Hoon Lee  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kyu Sik Jung  ;  Eun Hee Choi  ;  Young Nyun Park  ;  Kwang-Hyub Han  ;  Chae Yoon Chon  ;  Jun Yong Park 
Citation
 PLoS One, Vol.7(5) : e36676, 2012 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2012
Abstract
BACKGROUND: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) can assess liver fibrosis noninvasively. This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis. METHODS: Between March 2006 and April 2010, 128 CHB patients with who underwent LSM and liver biopsy (LB) before starting nucleot(s)ide analogues and showed histologically advanced fibrosis (≥F3) with a high viral loads [HBV DNA ≥2,000 IU/mL] were enrolled. All patients were followed regularly to detect LRE development, including hepatic decompensation (variceal bleeding, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome) and hepatocellular carcinoma (HCC). RESULTS: The mean age of the patient (72 men, 56 women) was 52.2 years. During the median follow-up period [median 27.8 (12.6-61.6) months], LREs developed in 19 (14.8%) patients (five with hepatic decompensation, 13 with HCC, one with both). Together with age, multivariate analysis identified LSM as an independent predictor of LRE development [P<0.044; hazard ratio (HR), 1.038; 95% confidence interval (CI), 1.002-1.081]. When the study population was stratified into two groups using the optimal cutoff value (19 kPa), which maximized the sum of sensitivity (61.1%) and specificity (86.2%) from a time-dependent receiver operating characteristic curve, patients with LSM>19 kPa were at significantly greater risk than those with LSM≤19 kPa for LRE development (HR, 7.176; 95% CI, 2.257-22.812; P = 0.001). CONCLUSION: LSM can be a useful predictor of LRE development in CHB patients showing histologically advanced liver fibrosis.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91692
DOI
10.1371/journal.pone.0036676
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김도영(Kim, Do Young) ; 김승업(Kim, Seung Up) ; 박영년(Park, Young Nyun) ; 박준용(Park, Jun Yong) ; 안상훈(Ahn, Sang Hoon) ; 이지훈(Lee, Ji Hoon) ; 전재윤(Chon, Chae Yoon) ; 정규식(Jung, Kyu Sik) ; 최은희(Choi, Eun Hee) ; 한광협(Han, Kwang Hyup)
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