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Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis

DC FieldValueLanguage
dc.contributor.author박영년-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이지훈-
dc.contributor.author전재윤-
dc.contributor.author정규식-
dc.contributor.author김도영-
dc.contributor.author최은희-
dc.contributor.author김승업-
dc.contributor.author한광협-
dc.date.accessioned2014-12-19T17:35:20Z-
dc.date.available2014-12-19T17:35:20Z-
dc.date.issued2012-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91692-
dc.description.abstractBACKGROUND: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) can assess liver fibrosis noninvasively. This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis. METHODS: Between March 2006 and April 2010, 128 CHB patients with who underwent LSM and liver biopsy (LB) before starting nucleot(s)ide analogues and showed histologically advanced fibrosis (≥F3) with a high viral loads [HBV DNA ≥2,000 IU/mL] were enrolled. All patients were followed regularly to detect LRE development, including hepatic decompensation (variceal bleeding, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome) and hepatocellular carcinoma (HCC). RESULTS: The mean age of the patient (72 men, 56 women) was 52.2 years. During the median follow-up period [median 27.8 (12.6-61.6) months], LREs developed in 19 (14.8%) patients (five with hepatic decompensation, 13 with HCC, one with both). Together with age, multivariate analysis identified LSM as an independent predictor of LRE development [P<0.044; hazard ratio (HR), 1.038; 95% confidence interval (CI), 1.002-1.081]. When the study population was stratified into two groups using the optimal cutoff value (19 kPa), which maximized the sum of sensitivity (61.1%) and specificity (86.2%) from a time-dependent receiver operating characteristic curve, patients with LSM>19 kPa were at significantly greater risk than those with LSM≤19 kPa for LRE development (HR, 7.176; 95% CI, 2.257-22.812; P = 0.001). CONCLUSION: LSM can be a useful predictor of LRE development in CHB patients showing histologically advanced liver fibrosis.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJi Hoon Lee-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKyu Sik Jung-
dc.contributor.googleauthorEun Hee Choi-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorJun Yong Park-
dc.identifier.doi10.1371/journal.pone.0036676-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01563-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA03223-
dc.contributor.localIdA03578-
dc.contributor.localIdA04163-
dc.contributor.localIdA00654-
dc.contributor.localIdA04268-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02540-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Ji Hoon-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameJung, Kyu Sik-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameChoi, Eun Hee-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Ji Hoon-
dc.contributor.affiliatedAuthorJung, Kyu Sik-
dc.contributor.affiliatedAuthorChoi, Eun Hee-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume7-
dc.citation.number5-
dc.citation.startPagee36676-
dc.identifier.bibliographicCitationPLoS One, Vol.7(5) : e36676, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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