97 208

Cited 0 times in

Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status)

Authors
 Jean Kyung Paik  ;  Ji Young Kim  ;  Oh Yoen Kim  ;  Yonghee Lee  ;  Tae-Sook Jeong  ;  Gary Sweeney  ;  Yangsoo Jang  ;  Jong Ho Lee 
Citation
 PLOS ONE, Vol.7(2) : e29675, 2012 
Journal Title
 PLOS ONE 
Issue Date
2012
MeSH
1-Alkyl-2-acetylglycerophosphocholine Esterase/analysis* ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/physiology* ; Adult ; Biomarkers ; Body Weight ; Case-Control Studies ; Female ; Humans ; Inflammation* ; Leukocytes, Mononuclear/chemistry* ; Lipoproteins, LDL ; Menopause/physiology* ; Middle Aged ; Oxidative Stress*
Keywords
1-Alkyl-2-acetylglycerophosphocholine Esterase/analysis* ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/physiology* ; Adult ; Biomarkers ; Body Weight ; Case-Control Studies ; Female ; Humans ; Inflammation* ; Leukocytes, Mononuclear/chemistry* ; Lipoproteins, LDL ; Menopause/physiology* ; Middle Aged ; Oxidative Stress*
Abstract
BACKGROUND: This study aimed to determine the association of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity in circulation and peripheral blood mononuclear cells (PBMCs) with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA(2) activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress. METHODOLOGY/PRINCIPAL FINDINGS: Eighty postmenopausal women (53.0±4.05 yr) and 96 premenopausal women (39.7±9.25 yr) participated in this study. Lp-PLA(2) activities, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β in plasma as well as in PBMCs were measured. Plasma ox-LDL was also measured. Postmenopausal women demonstrated higher circulating levels of ox-LDL and IL-6, as well as IL-6, TNF-α, and IL-1β in PBMCs, than premenopausal women. In both groups, plasma Lp-PLA(2) activity positively correlated with Lp-PLA(2) activity in PBMCs and plasma ox-LDL. In premenopausal women, Lp-PLA(2) activities in plasma and PBMCs positively correlated with IL-6, TNF-α, and IL-1β in PBMCs. In postmenopausal women, plasma ox-LDL positively correlated with PBMC cytokine production. In subgroup analysis of postmenopausal women according to plasma ox-LDL level (median level: 48.715 U/L), a significant increase in Lp-PLA(2) activity in the plasma but not the PBMCs was found in the high ox-LDL subgroup. Plasma Lp-PLA(2) activity positively correlated with unstimulated PBMC Lp-PLA(2) activity in the low ox-LDL subgroup (r = 0.627, P<0.001), whereas in the high ox-LDL circulating Lp-PLA(2) activity positively correlated with plasma ox-LDL (r = 0.390, P = 0.014) but not with Lp-PLA(2) activity in PBMCs. CONCLUSIONS/SIGNIFICANCE: The lack of relation between circulating Lp-PLA(2) activity and Lp-PLA(2) activity in PBMCs was found in postmenopausal women with high ox-LDL. This may indicate other sources of circulating Lp-PLA(2) activity except PBMC in postmenopausal women with high ox-LDL. We also demonstrated that circulating Lp-PLA(2) and PBMC secreted Lp-PLA(2) associate differently with markers of oxidative stress and sub clinical inflammation in nonobese women, particularly according to the menopausal states.
Files in This Item:
T201200269.pdf Download
DOI
22359537
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91673
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links