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Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status)

DC FieldValueLanguage
dc.contributor.author장양수-
dc.date.accessioned2014-12-19T17:34:44Z-
dc.date.available2014-12-19T17:34:44Z-
dc.date.issued2012-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91673-
dc.description.abstractBACKGROUND: This study aimed to determine the association of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity in circulation and peripheral blood mononuclear cells (PBMCs) with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA(2) activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress. METHODOLOGY/PRINCIPAL FINDINGS: Eighty postmenopausal women (53.0±4.05 yr) and 96 premenopausal women (39.7±9.25 yr) participated in this study. Lp-PLA(2) activities, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β in plasma as well as in PBMCs were measured. Plasma ox-LDL was also measured. Postmenopausal women demonstrated higher circulating levels of ox-LDL and IL-6, as well as IL-6, TNF-α, and IL-1β in PBMCs, than premenopausal women. In both groups, plasma Lp-PLA(2) activity positively correlated with Lp-PLA(2) activity in PBMCs and plasma ox-LDL. In premenopausal women, Lp-PLA(2) activities in plasma and PBMCs positively correlated with IL-6, TNF-α, and IL-1β in PBMCs. In postmenopausal women, plasma ox-LDL positively correlated with PBMC cytokine production. In subgroup analysis of postmenopausal women according to plasma ox-LDL level (median level: 48.715 U/L), a significant increase in Lp-PLA(2) activity in the plasma but not the PBMCs was found in the high ox-LDL subgroup. Plasma Lp-PLA(2) activity positively correlated with unstimulated PBMC Lp-PLA(2) activity in the low ox-LDL subgroup (r = 0.627, P<0.001), whereas in the high ox-LDL circulating Lp-PLA(2) activity positively correlated with plasma ox-LDL (r = 0.390, P = 0.014) but not with Lp-PLA(2) activity in PBMCs. CONCLUSIONS/SIGNIFICANCE: The lack of relation between circulating Lp-PLA(2) activity and Lp-PLA(2) activity in PBMCs was found in postmenopausal women with high ox-LDL. This may indicate other sources of circulating Lp-PLA(2) activity except PBMC in postmenopausal women with high ox-LDL. We also demonstrated that circulating Lp-PLA(2) and PBMC secreted Lp-PLA(2) associate differently with markers of oxidative stress and sub clinical inflammation in nonobese women, particularly according to the menopausal states.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH1-Alkyl-2-acetylglycerophosphocholine Esterase/analysis*-
dc.subject.MESH1-Alkyl-2-acetylglycerophosphocholine Esterase/blood-
dc.subject.MESH1-Alkyl-2-acetylglycerophosphocholine Esterase/physiology*-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers-
dc.subject.MESHBody Weight-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammation*-
dc.subject.MESHLeukocytes, Mononuclear/chemistry*-
dc.subject.MESHLipoproteins, LDL-
dc.subject.MESHMenopause/physiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOxidative Stress*-
dc.titleCirculating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJean Kyung Paik-
dc.contributor.googleauthorJi Young Kim-
dc.contributor.googleauthorOh Yoen Kim-
dc.contributor.googleauthorYonghee Lee-
dc.contributor.googleauthorTae-Sook Jeong-
dc.contributor.googleauthorGary Sweeney-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorJong Ho Lee-
dc.identifier.doi22359537-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03448-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid22359537-
dc.subject.keyword1-Alkyl-2-acetylglycerophosphocholine Esterase/analysis*-
dc.subject.keyword1-Alkyl-2-acetylglycerophosphocholine Esterase/blood-
dc.subject.keyword1-Alkyl-2-acetylglycerophosphocholine Esterase/physiology*-
dc.subject.keywordAdult-
dc.subject.keywordBiomarkers-
dc.subject.keywordBody Weight-
dc.subject.keywordCase-Control Studies-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordInflammation*-
dc.subject.keywordLeukocytes, Mononuclear/chemistry*-
dc.subject.keywordLipoproteins, LDL-
dc.subject.keywordMenopause/physiology*-
dc.subject.keywordMiddle Aged-
dc.subject.keywordOxidative Stress*-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.citation.volume7-
dc.citation.number2-
dc.citation.startPagee29675-
dc.identifier.bibliographicCitationPLOS ONE, Vol.7(2) : e29675, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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