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Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats

 Seo Hee Lee  ;  Hyun Joo Lee  ;  Yong-ho Lee  ;  Byung-Wan Lee  ;  Bong Soo Cha  ;  Eun Seok Kang  ;  Chul Woo Ahn  ;  Jong Sook Park  ;  Hyo Jeong Kim  ;  Eun Young Lee  ;  Hyun Chul Lee 
 PHYTOTHERAPY RESEARCH, Vol.26(1) : 142-147, 2012 
Journal Title
Issue Date
Adipokines/metabolism ; Adipose Tissue/drug effects* ; Adipose Tissue/metabolism ; Animals ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/therapeutic use* ; Blotting, Western ; Diet, High-Fat/adverse effects* ; Dietary Fats/adverse effects ; Disease Models, Animal ; Glucose Transporter Type 4/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use* ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Resistance* ; Male ; Muscle, Skeletal/metabolism ; Panax* ; Phosphorylation ; Phytotherapy* ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptor, Insulin/metabolism ; Signal Transduction/drug effects ; Weight Loss/drug effects
Korean red ginseng ; insulin sensitivity ; diabet es
Many studies have documented that ginseng has antidiabetic and antiobesity effects, but the mechanism of the effects has not been elucidated. The aim of this study was to determine the effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism of antidiabetic and antiobesity effects in obese insulin resistant animal models. Sprague-Dawley (SD) rats were divided into three groups: a control group (group I) fed a normal diet, another group (group II) fed only high fat diet (HFD) and a third group (group III) fed HFD with KRG (200 mg/kg, oral) for 18 weeks. The body weight, food intake, adipose tissues, liver, kidney, pancreas, adiponectin, and leptin were measured. Blood glucose, insulin tolerance test, and hyperinsulinemic euglycemic clamp test were investigated. A significant weight reduction, especially fat mass reduction, was observed in the KRG treated group. Increased insulin sensitivity was found in the KRG treated group. We observed increased insulin signalling, increased phosphorylation of IR, IRS-1, Akt, and membranous GLUT4 in muscle by Western blotting assay. In conclusion, KRG may have antidiabetic and antiobesity effects due to partly increased insulin sensitivity by increased adipokine and partly enhanced insulin signalling.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Seo Hee(이서희)
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Eun Young(이은영)
Lee, Hyun Joo(이현주)
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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