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Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이서희 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 이은영 | - |
dc.contributor.author | 이현주 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2014-12-19T17:34:33Z | - |
dc.date.available | 2014-12-19T17:34:33Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91667 | - |
dc.description.abstract | Many studies have documented that ginseng has antidiabetic and antiobesity effects, but the mechanism of the effects has not been elucidated. The aim of this study was to determine the effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism of antidiabetic and antiobesity effects in obese insulin resistant animal models. Sprague-Dawley (SD) rats were divided into three groups: a control group (group I) fed a normal diet, another group (group II) fed only high fat diet (HFD) and a third group (group III) fed HFD with KRG (200 mg/kg, oral) for 18 weeks. The body weight, food intake, adipose tissues, liver, kidney, pancreas, adiponectin, and leptin were measured. Blood glucose, insulin tolerance test, and hyperinsulinemic euglycemic clamp test were investigated. A significant weight reduction, especially fat mass reduction, was observed in the KRG treated group. Increased insulin sensitivity was found in the KRG treated group. We observed increased insulin signalling, increased phosphorylation of IR, IRS-1, Akt, and membranous GLUT4 in muscle by Western blotting assay. In conclusion, KRG may have antidiabetic and antiobesity effects due to partly increased insulin sensitivity by increased adipokine and partly enhanced insulin signalling. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipokines/metabolism | - |
dc.subject.MESH | Adipose Tissue/drug effects* | - |
dc.subject.MESH | Adipose Tissue/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Obesity Agents/pharmacology | - |
dc.subject.MESH | Anti-Obesity Agents/therapeutic use* | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Diet, High-Fat/adverse effects* | - |
dc.subject.MESH | Dietary Fats/adverse effects | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Glucose Transporter Type 4/metabolism | - |
dc.subject.MESH | Hypoglycemic Agents/pharmacology | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use* | - |
dc.subject.MESH | Insulin Receptor Substrate Proteins/metabolism | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscle, Skeletal/metabolism | - |
dc.subject.MESH | Panax* | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Phytotherapy* | - |
dc.subject.MESH | Plant Extracts/pharmacology | - |
dc.subject.MESH | Plant Extracts/therapeutic use | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptor, Insulin/metabolism | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Weight Loss/drug effects | - |
dc.title | Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seo Hee Lee | - |
dc.contributor.googleauthor | Hyun Joo Lee | - |
dc.contributor.googleauthor | Yong-ho Lee | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Jong Sook Park | - |
dc.contributor.googleauthor | Hyo Jeong Kim | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 22034219 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A02850 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A03297 | - |
dc.contributor.localId | A03042 | - |
dc.contributor.localId | A01660 | - |
dc.relation.journalcode | J02531 | - |
dc.identifier.eissn | 1099-1573 | - |
dc.identifier.pmid | 22034219 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/ptr.3610/abstract | - |
dc.subject.keyword | Korean red ginseng | - |
dc.subject.keyword | insulin sensitivity | - |
dc.subject.keyword | diabet es | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Park, Jong Suk | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Seo Hee | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.alternativeName | Lee, Eung Young | - |
dc.contributor.alternativeName | Lee, Hyun Joo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Seo Hee | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Joo | - |
dc.contributor.affiliatedAuthor | Lee, Eun Young | - |
dc.contributor.affiliatedAuthor | Park, Jong Suk | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 147 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, Vol.26(1) : 142-147, 2012 | - |
dc.identifier.rimsid | 29549 | - |
dc.type.rims | ART | - |
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