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Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast

Authors
 Kim D.  ;  Jung W.-H.  ;  Koo J.S. 
Citation
 PATHOBIOLOGY, Vol.79(3) : 144-153, 2012 
Journal Title
 PATHOBIOLOGY 
ISSN
 1015-2008 
Issue Date
2012
MeSH
Adenocarcinoma, Mucinous/metabolism* ; Adenocarcinoma, Mucinous/pathology* ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology* ; Female ; Humans ; Immunohistochemistry ; Mucin 5AC/metabolism ; Mucin-1/metabolism ; Mucin-2/metabolism ; Mucin-5B/metabolism ; Mucins/metabolism*
Keywords
Breast ; Mucin ; Mucinous carcinoma ; Mucocele-like lesion ; Solid papillary carcinoma
Abstract
OBJECTIVE: The purpose of this study was to investigate the expression of MUC1, MUC2, MUC5AC and MUC5B in breast mucinous lesions. METHODS: Immunohistochemical staining of MUC1, MUC2, MUC5AC, MUC5B and synaptophysin was performed in 78 cases of mucinous carcinoma (MC), 36 cases of mucocele-like lesions (MLL) and 13 cases of solid papillary carcinoma (SPC). MC was classified as type A or type B and MLL was classified as MLL, MLL with atypical ductal hyperplasia and MLL with ductal carcinoma in situ. RESULTS: MUC1 was expressed in MC type A and MLL with luminal/apical pattern, while MC type B and SPC showed membrano-cytoplasmic expression of MUC1 (p < 0.001). A luminal/apical or luminal/apical + cytoplasmic pattern of MUC2 expression was observed in MC type A, while MC type B and SPC showed membrano-cytoplasmic MUC2 expression (p < 0.001). On MUC5B staining, MC type A and MLL were negative, while MC type B and SPC showed membrano-cytoplasmic expression (p = 0.011). The positive rate for synaptophysin was higher in MC type B and SPC than in MLL and MC type A (p = 0.001). CONCLUSIONS: Similar MUC phenotypes were observed between MLL and MC type A and between MC type B and SPC.
Full Text
http://www.karger.com/Article/FullText/334086
DOI
22269464
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91640
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