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Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2014-12-19T17:33:42Z | - |
dc.date.available | 2014-12-19T17:33:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91640 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to investigate the expression of MUC1, MUC2, MUC5AC and MUC5B in breast mucinous lesions. METHODS: Immunohistochemical staining of MUC1, MUC2, MUC5AC, MUC5B and synaptophysin was performed in 78 cases of mucinous carcinoma (MC), 36 cases of mucocele-like lesions (MLL) and 13 cases of solid papillary carcinoma (SPC). MC was classified as type A or type B and MLL was classified as MLL, MLL with atypical ductal hyperplasia and MLL with ductal carcinoma in situ. RESULTS: MUC1 was expressed in MC type A and MLL with luminal/apical pattern, while MC type B and SPC showed membrano-cytoplasmic expression of MUC1 (p < 0.001). A luminal/apical or luminal/apical + cytoplasmic pattern of MUC2 expression was observed in MC type A, while MC type B and SPC showed membrano-cytoplasmic MUC2 expression (p < 0.001). On MUC5B staining, MC type A and MLL were negative, while MC type B and SPC showed membrano-cytoplasmic expression (p = 0.011). The positive rate for synaptophysin was higher in MC type B and SPC than in MLL and MC type A (p = 0.001). CONCLUSIONS: Similar MUC phenotypes were observed between MLL and MC type A and between MC type B and SPC. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PATHOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/metabolism* | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/pathology* | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Mucin 5AC/metabolism | - |
dc.subject.MESH | Mucin-1/metabolism | - |
dc.subject.MESH | Mucin-2/metabolism | - |
dc.subject.MESH | Mucin-5B/metabolism | - |
dc.subject.MESH | Mucins/metabolism* | - |
dc.title | Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Kim D. | - |
dc.contributor.googleauthor | Jung W.-H. | - |
dc.contributor.googleauthor | Koo J.S. | - |
dc.identifier.doi | 22269464 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J02470 | - |
dc.identifier.eissn | 1423-0291 | - |
dc.identifier.pmid | 22269464 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/334086 | - |
dc.subject.keyword | Breast | - |
dc.subject.keyword | Mucin | - |
dc.subject.keyword | Mucinous carcinoma | - |
dc.subject.keyword | Mucocele-like lesion | - |
dc.subject.keyword | Solid papillary carcinoma | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 79 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 144 | - |
dc.citation.endPage | 153 | - |
dc.identifier.bibliographicCitation | PATHOBIOLOGY, Vol.79(3) : 144-153, 2012 | - |
dc.identifier.rimsid | 29528 | - |
dc.type.rims | ART | - |
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