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Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma

 Kim D.  ;  Kim H.  ;  Koo J.S. 
 PATHOBIOLOGY, Vol.79(1) : 1-10, 2012 
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Issue Date
Adult ; Aged ; Aged, 80 and over ; Cadherins/metabolism ; Carcinoma ; Carcinoma, Papillary/metabolism* ; Carcinoma, Papillary/pathology ; Caveolin 1/metabolism* ; Caveolin 2/metabolism* ; Caveolin 3/metabolism* ; Epithelial-Mesenchymal Transition/physiology ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Thyroid Neoplasms/metabolism* ; Thyroid Neoplasms/pathology
Anaplastic carcinoma ; Caveolin ; Epithelial-mesenchymal transition ; Myofibroblast ; Thyroid cancer
OBJECTIVE: To study the expression status of caveolin-1, caveolin-2 and caveolin-3 in the epithelial and stromal compartments of conventional papillary thyroid carcinoma (PTC), diffuse sclerosing variant of papillary carcinoma (DSVPC) and anaplastic carcinoma (AC). METHODS: Tissue microarrays were constructed from 70 PTC, 41 DSVPC and 12 AC, and immunohistochemical stains were performed with caveolin-1, caveolin-2, caveolin-3, cytokeratin, vimentin and E-cadherin. The expression status of these markers in the epithelial and stromal cells was evaluated, and the results were correlated with the clinicopathologic variables. RESULTS: Epithelial caveolin-3 expression was absent in the majority of PTC and DSPVC, and was significantly increased in AC (p < 0.001). The stromal expression of caveolin-1, caveolin-2 and caveolin-3 increased in frequency from PTC to DSVPC to AC, and was significantly increased in the stroma of AC (p < 0.001). Cytokeratin and E-cadherin were more frequently negative in AC compared to PTC (p = 0.003) and DSVPC (p < 0.001), while vimentin was more frequently expressed in AC compared to PTC and DSVPC (both p < 0.001). CONCLUSION: Epithelial caveolin-3 expression is increased in AC compared to PTC and DSVPC, and this may be linked to the epithelial-mesenchymal transition process of AC. In addition, stromal caveolin-1, caveolin-2 and caveolin-3 expression was more frequent in AC compared to PTC and DSVPC, and the specific expression of caveolin-3 in the stroma of AC could suggest a possible role of myofibroblasts. Copyright © 2012 S. Karger AG, Basel.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
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