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Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma

DC FieldValueLanguage
dc.contributor.author구자승-
dc.date.accessioned2014-12-19T17:33:40Z-
dc.date.available2014-12-19T17:33:40Z-
dc.date.issued2012-
dc.identifier.issn1015-2008-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91639-
dc.description.abstractOBJECTIVE: To study the expression status of caveolin-1, caveolin-2 and caveolin-3 in the epithelial and stromal compartments of conventional papillary thyroid carcinoma (PTC), diffuse sclerosing variant of papillary carcinoma (DSVPC) and anaplastic carcinoma (AC). METHODS: Tissue microarrays were constructed from 70 PTC, 41 DSVPC and 12 AC, and immunohistochemical stains were performed with caveolin-1, caveolin-2, caveolin-3, cytokeratin, vimentin and E-cadherin. The expression status of these markers in the epithelial and stromal cells was evaluated, and the results were correlated with the clinicopathologic variables. RESULTS: Epithelial caveolin-3 expression was absent in the majority of PTC and DSPVC, and was significantly increased in AC (p < 0.001). The stromal expression of caveolin-1, caveolin-2 and caveolin-3 increased in frequency from PTC to DSVPC to AC, and was significantly increased in the stroma of AC (p < 0.001). Cytokeratin and E-cadherin were more frequently negative in AC compared to PTC (p = 0.003) and DSVPC (p < 0.001), while vimentin was more frequently expressed in AC compared to PTC and DSVPC (both p < 0.001). CONCLUSION: Epithelial caveolin-3 expression is increased in AC compared to PTC and DSVPC, and this may be linked to the epithelial-mesenchymal transition process of AC. In addition, stromal caveolin-1, caveolin-2 and caveolin-3 expression was more frequent in AC compared to PTC and DSVPC, and the specific expression of caveolin-3 in the stroma of AC could suggest a possible role of myofibroblasts. Copyright © 2012 S. Karger AG, Basel.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~10-
dc.relation.isPartOfPathobiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleExpression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorKim D.-
dc.contributor.googleauthorKim H.-
dc.contributor.googleauthorKoo J.S.-
dc.identifier.doi10.1159/000329472-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.relation.journalcodeJ02470-
dc.identifier.urlhttp://www.karger.com/Article/FullText/329472-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume79-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage10-
dc.identifier.bibliographicCitationPathobiology, Vol.79(1) : 1-10, 2012-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)

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