Cited 19 times in
Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.date.accessioned | 2014-12-19T17:33:40Z | - |
dc.date.available | 2014-12-19T17:33:40Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91639 | - |
dc.description.abstract | OBJECTIVE: To study the expression status of caveolin-1, caveolin-2 and caveolin-3 in the epithelial and stromal compartments of conventional papillary thyroid carcinoma (PTC), diffuse sclerosing variant of papillary carcinoma (DSVPC) and anaplastic carcinoma (AC). METHODS: Tissue microarrays were constructed from 70 PTC, 41 DSVPC and 12 AC, and immunohistochemical stains were performed with caveolin-1, caveolin-2, caveolin-3, cytokeratin, vimentin and E-cadherin. The expression status of these markers in the epithelial and stromal cells was evaluated, and the results were correlated with the clinicopathologic variables. RESULTS: Epithelial caveolin-3 expression was absent in the majority of PTC and DSPVC, and was significantly increased in AC (p < 0.001). The stromal expression of caveolin-1, caveolin-2 and caveolin-3 increased in frequency from PTC to DSVPC to AC, and was significantly increased in the stroma of AC (p < 0.001). Cytokeratin and E-cadherin were more frequently negative in AC compared to PTC (p = 0.003) and DSVPC (p < 0.001), while vimentin was more frequently expressed in AC compared to PTC and DSVPC (both p < 0.001). CONCLUSION: Epithelial caveolin-3 expression is increased in AC compared to PTC and DSVPC, and this may be linked to the epithelial-mesenchymal transition process of AC. In addition, stromal caveolin-1, caveolin-2 and caveolin-3 expression was more frequent in AC compared to PTC and DSVPC, and the specific expression of caveolin-3 in the stroma of AC could suggest a possible role of myofibroblasts. Copyright © 2012 S. Karger AG, Basel. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PATHOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Cadherins/metabolism | - |
dc.subject.MESH | Carcinoma | - |
dc.subject.MESH | Carcinoma, Papillary/metabolism* | - |
dc.subject.MESH | Carcinoma, Papillary/pathology | - |
dc.subject.MESH | Caveolin 1/metabolism* | - |
dc.subject.MESH | Caveolin 2/metabolism* | - |
dc.subject.MESH | Caveolin 3/metabolism* | - |
dc.subject.MESH | Epithelial-Mesenchymal Transition/physiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Thyroid Neoplasms/metabolism* | - |
dc.subject.MESH | Thyroid Neoplasms/pathology | - |
dc.title | Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Kim D. | - |
dc.contributor.googleauthor | Kim H. | - |
dc.contributor.googleauthor | Koo J.S. | - |
dc.identifier.doi | 10.1159/000329472 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J02470 | - |
dc.identifier.eissn | 1423-0291 | - |
dc.identifier.pmid | 22236542 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/329472 | - |
dc.subject.keyword | Anaplastic carcinoma | - |
dc.subject.keyword | Caveolin | - |
dc.subject.keyword | Epithelial-mesenchymal transition | - |
dc.subject.keyword | Myofibroblast | - |
dc.subject.keyword | Thyroid cancer | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 79 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.identifier.bibliographicCitation | PATHOBIOLOGY, Vol.79(1) : 1-10, 2012 | - |
dc.identifier.rimsid | 29527 | - |
dc.type.rims | ART | - |
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