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Pancreatoduodenectomy following neoadjuvant chemoradiation therapy in uncinate process pancreatic cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명진 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 정재복 | - |
dc.contributor.author | 최진영 | - |
dc.contributor.author | 강창무 | - |
dc.date.accessioned | 2014-12-19T17:33:20Z | - |
dc.date.available | 2014-12-19T17:33:20Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0885-3177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91628 | - |
dc.description.abstract | OBJECTIVE: The objective of the study was to delineate surgical outcomes of pancreatoduodenectomy following neoadjuvant concurrent chemoradiation therapy (CCRT) in uncinate process pancreatic cancer (UPC). METHODS: We reviewed 97 patients with resected usual pancreatic head cancer (PHC) and UPC and analyzed clinicopathologic characteristics and survival outcomes of PHC and UPC with a review of the reported literature regarding UPC. RESULTS: Twenty-five patients (27.8%) had UPC, and 72 patients had PHC. Pylorus-preserving pancreatoduodenectomy was performed in 67 patients (69.1%) and conventional pancreatoduodenectomy in 28 patients (28.9%), and 2 patients needed total pancreatectomies. When comparing UPCs with PHCs, less frequent jaundice (P = 0.009) and more advanced stages of cancers at the time of diagnosis (linear-to-linear association, P = 0.03) were found in UPCs, and CCRT was administered more frequently in UPCs (P = 0.013). Survival outcomes between PHC and UPC were similar, with median survival rates of 25.9 and 30.5 months, respectively (P = 0.702). In addition, disease-free survival was similar between the 2 groups (15.6 and 15.2 months, respectively; P = 0.4503). Our oncologic outcome of pancreatectomy for UPC is likely to be more acceptable compared with those previously reported in the literature. CONCLUSIONS: Although UPCs are found in relatively advanced clinical stages, favorable oncologic outcomes may be obtained by pancreatectomy following preoperative CCRT. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PANCREAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/drug therapy | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/mortality | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/pathology | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/surgery | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/therapy* | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant/adverse effects | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy/methods* | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Pancreatic Neoplasms/drug therapy | - |
dc.subject.MESH | Pancreatic Neoplasms/mortality | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology | - |
dc.subject.MESH | Pancreatic Neoplasms/radiotherapy | - |
dc.subject.MESH | Pancreatic Neoplasms/surgery | - |
dc.subject.MESH | Pancreatic Neoplasms/therapy* | - |
dc.subject.MESH | Pancreaticoduodenectomy*/adverse effects | - |
dc.subject.MESH | Pancreaticoduodenectomy*/mortality | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Pancreatoduodenectomy following neoadjuvant chemoradiation therapy in uncinate process pancreatic cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Kang, Chang Moo | - |
dc.contributor.googleauthor | Choi, Jin-Young | - |
dc.contributor.googleauthor | Seong, Jin Sil | - |
dc.contributor.googleauthor | Song, Si Young | - |
dc.contributor.googleauthor | Lee, Woo Jung | - |
dc.contributor.googleauthor | Kim, Myung-Jin | - |
dc.contributor.googleauthor | Chung, Jae Bock | - |
dc.identifier.doi | 22158068 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03706 | - |
dc.contributor.localId | A04200 | - |
dc.contributor.localId | A00088 | - |
dc.contributor.localId | A02993 | - |
dc.relation.journalcode | J02463 | - |
dc.identifier.eissn | 1536-4828 | - |
dc.identifier.pmid | 22158068 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201204000-00017&LSLINK=80&D=ovft | - |
dc.subject.keyword | uncinate process | - |
dc.subject.keyword | pancreatic cancer | - |
dc.subject.keyword | pancreatectomy | - |
dc.subject.keyword | preoperative chemoradiation | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.alternativeName | Chung, Jae Bock | - |
dc.contributor.alternativeName | Choi, Jin Young | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Chung, Jae Bock | - |
dc.contributor.affiliatedAuthor | Choi, Jin Young | - |
dc.contributor.affiliatedAuthor | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.citation.volume | 41 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 467 | - |
dc.citation.endPage | 473 | - |
dc.identifier.bibliographicCitation | PANCREAS, Vol.41(3) : 467-473, 2012 | - |
dc.identifier.rimsid | 29522 | - |
dc.type.rims | ART | - |
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