4 139

Significant reduction of atrial defibrillation threshold and inducibility by catheter ablation of atrial fibrillation.

Authors
 EUI-SEOCK HWANG  ;  GI BYUNG NAM  ;  BOYOUNG JOUNG  ;  JUNBEOM PARK  ;  JIHEI SARA LEE  ;  JAEMIN SHIM  ;  JAE-SUN UHM  ;  MOON HYOUNG LEE  ;  HUI-NAM PAK 
Citation
 PACE - Pacing and Clinical Electrophysiology, Vol.35(12) : 1428-1435, 2012 
Journal Title
 PACE - Pacing and Clinical Electrophysiology 
ISSN
 0147-8389 
Issue Date
2012
Abstract
Background: Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) has antiarrhythmic effects by multiple mechanisms. We hypothesized that RFCA curtails atrial defibrillation threshold (A-DFT) and postablation induction pacing cycle length (iPCL), making critical mass reduction one potential mechanism by which antiarrhythmic effect is achieved. Methods: We included 289 patients with AF (male 77.9%, 55.7 ± 10.8 years old; 197 paroxysmal AF: 92 persistent AF) who underwent RFCA. A-DFT (serial internal cardioversion 2, 3, 5, 7, and 10 J) and iPCL (serial 10 mA 10-second atrial pacing with pacing cycle length 250, 200, 190, 180, 170, 160, and 150 ms) were evaluated before and after RFCA. Results: (1) RFCA of AF reduced the A-DFT from 6.7 ± 3.7 J to 3.0 ± 3.0 J (P < 0.001). (2) AF ablation reduced AF inducibility from 95.4% before the procedure to 56.3% after the procedure (P < 0.001), and the iPCL from 194.8 ± 32.6 to 160.9 ± 26.2 ms (P < 0.001). (3) In patients who underwent a greater number of ablation lines, the post-RFCA A-DFT (P < 0.001) was lower, and %ΔA-DFT (P = 0.003) and proportion of atrial tachycardia (P = 0.022) were higher than those with a lower number of ablation lines. Conclusion: AF ablation significantly reduced A-DFT, AF inducibility, and iPCL, and the degree of their reduction was related to the number of ablation lines.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91627
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8159.2012.03517.x/abstract
DOI
10.1111/j.1540-8159.2012.03517.x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박준범(Park, Jun Beom)
박희남(Pak, Hui Nam) ORCID logo https://orcid.org/0000-0002-3256-3620
심재민(Shim, Jae Min)
엄재선(Uhm, Jae Sun)
이문형(Lee, Moon Hyoung) ORCID logo https://orcid.org/0000-0002-7268-0741
정보영(Joung, Bo Young)
황의석(Hwang, Eui Seock)
Export
RIS (EndNote)
XLS (Excel)
XML
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse