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Seven Year-follow-up of a Brown Tumor in the Maxilla Associated with Secondary Hyperparathyroidism in End-stage Renal Failure

Other Titles
 말기 신부전 환자에서 이차성 부갑상선 기능 항진증과 연관하여 상악골에 발생한 갈색종의 7년간 추적 결과 1예 
Authors
 김원진  ;  김다함  ;  이유미  ;  임승길  ;  이수진 
Citation
 Osteoporosis, Vol.10(2) : 82-89, 2012 
Journal Title
 Osteoporosis 
ISSN
 20939361 
Issue Date
2012
Abstract
Hyperparathyroidism is a frequent complication of chronic kidney disease (CKD) as a result of prolonged hyperphosphatemia and hypocalcemia. Brown tumor is a rare bony complication of hyperparathyroidism as a result of increased osteoclastic activity and fibroblastic proliferation. Frequent sites of brown tumor are known as ribs, clavicles, mandible, and pelvic bone, but maxilla is very rare site. Twenty seven-year-old woman with stage V CKD on hemodialysis presented with maxillary mass which had gradually increased in size for 3 years. It was painless, but tooth derangement occurred. Initial laboratory findings revealed hypercalcemia (11.0 mg/dL), hyperphosphatemia (6.9 mg/dL), high creatinine (7.5 mg/dL), and high serum PTH (1729.9 pg/mL). The bone mineral density was significantly low (lumbar spine Z-score: -4.1, femur neck Z-score: -4.5). Radiologically, there were resorptive lesions in the maxilla. We performed total parathyroidectomy with transplanting half of her parathyroid gland on her right forearm. After surgery, serum PTH was markedly decreased to normal level. Immediate post-operative hypocalcemia developed without any change in serum Pi, then calcium gradually normalized. Seven years after the parathyroid surgery, she finally underwent renal transplantation that lead her calcium, phosphate and creatinine corrected to normal range, and the size of brown tumor has decreased further more. We report a case of long term follow up on a brown tumor in the maxilla which is infrequent site finally recovered.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91620
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry & Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김다함(Kim, Da Ham) ; 김원진(Kim, Won Jin) ; 이수진(Lee, Su Jin) ; 이유미(Rhee, Yumie) ; 임승길(Lim, Sung Kil)
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