0 237

Cited 0 times in

Biomarker detection for the diagnosis of lymph node metastasis from oral squamous cell carcinoma

 Ki-Yeol Kima  ;  Gui Youn Leeb  ;  In-Ho Chaa 
 ORAL ONCOLOGY, Vol.48(4) : 311-319, 2012 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics* ; Carcinoma, Squamous Cell/genetics* ; Carcinoma, Squamous Cell/secondary ; Female ; Gene Expression ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/genetics* ; Male ; Microarray Analysis ; Middle Aged ; Mouth Neoplasms/genetics* ; Mouth Neoplasms/pathology
Lymph node metastasis ; Biomarker ; Gene expression ; Microarray data ; Combined dataset ; Array comparative genomic hybridization (aCGH) data ; Oral squamous cell carcinoma
Lymph node metastasis is an important prognostic factor in oral squamous cell carcinoma. However, the lack of significant biomarkers for lymph node metastasis can cause patients to be inappropriately treated and produce a poor prognosis. Therefore, there is a need to identify gene sets that are associated with lymph node metastasis. In this study, we used three expression datasets obtained from a public database and selected candidate gene sets that were related with lymph node metastasis from two datasets and a combined dataset. We evaluated the selected gene set using OOB error rates in a validation dataset. The gene set detected from the combined dataset classified the lymph node status more accurately in the validation dataset and clear expression patterns classifying the lymph node status based on chromosomal location were observed. The combined dataset holds promise for use as a more accurate candidate gene set for the diagnosis of lymph node metastasis and the selected gene set could be used for biological validation in further studies.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Lee, Gui Youn(이귀연)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.