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Biomarker detection for the diagnosis of lymph node metastasis from oral squamous cell carcinoma

Authors
 Ki-Yeol Kima  ;  Gui Youn Leeb  ;  In-Ho Chaa 
Citation
 Oral Oncology, Vol.48(4) : 311-319, 2012 
Journal Title
 Oral Oncology 
ISSN
 1368-8375 
Issue Date
2012
Abstract
Lymph node metastasis is an important prognostic factor in oral squamous cell carcinoma. However, the lack of significant biomarkers for lymph node metastasis can cause patients to be inappropriately treated and produce a poor prognosis. Therefore, there is a need to identify gene sets that are associated with lymph node metastasis. In this study, we used three expression datasets obtained from a public database and selected candidate gene sets that were related with lymph node metastasis from two datasets and a combined dataset. We evaluated the selected gene set using OOB error rates in a validation dataset. The gene set detected from the combined dataset classified the lymph node status more accurately in the validation dataset and clear expression patterns classifying the lymph node status based on chromosomal location were observed. The combined dataset holds promise for use as a more accurate candidate gene set for the diagnosis of lymph node metastasis and the selected gene set could be used for biological validation in further studies.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91606
Full Text
http://www.sciencedirect.com/science/article/pii/S1368837511008992
DOI
10.1016/j.oraloncology.2011.11.010
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
Yonsei Authors
김기열(Kim, Ki Yeol)
이귀연(Lee, Gui Youn)
차인호(Cha, In Ho) ORCID logo https://orcid.org/0000-0001-8259-2190
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