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Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer

 Jae-Heon Jeong  ;  Sun Min Lim  ;  Ji Young Yun  ;  Gwang Won Rhee  ;  Jae Yun Lim  ;  Jae Yong Cho  ;  Yu Ri Kim 
 Oncology, Vol.83(5) : 292-299, 2012 
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OBJECTIVES: The objective of this study was to compare the usefulness of two inflammation-based prognostic scores, neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), assessed at diagnosis in stage IV advanced gastric cancer (AGC). METHODS: We retrospectively reviewed the medical records of 104 patients with newly diagnosed metastatic AGC treated with palliative chemotherapy. RESULTS: In the univariate analysis, the following variables were associated with shorter overall survival (OS): poor or undifferentiated histology (p = 0.013), more than 1 metastasis (p = 0.004), the presence of lymph node metastasis (p = 0.003), the presence of bone metastasis (p = 0.019), a lower albumin level (p < 0.001), elevated C-reactive protein (p < 0.001), a high absolute neutrophil count (p = 0.016), NLR ≥3 (p < 0.001) and higher mGPS (p < 0.001 and p = 0.007, respectively). In the multivariate analysis, high NLR and mGPS were independent prognostic factors for shorter OS (p = 0.037, p < 0.001 and p = 0.010, respectively), along with lymph node metastasis (p = 0.005) and histological subtype (p = 0.048). CONCLUSION: This study suggests that the inflammatory markers, NLR and mGPS, are independent prognostic factors for OS in patients with unresectable AGC treated with palliative chemotherapy. Copyright © 2012 S. Karger AG, Basel.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김유리(Kim, Yu Ri) ORCID logo https://orcid.org/0000-0001-5505-0142
임선민(Lim, Sun Min)
임재윤(Lim, Jae Yun)
조재용(Cho, Jae Yong) ORCID logo https://orcid.org/0000-0002-0926-1819
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