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Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer

Authors
 Jae-Heon Jeong ; Sun Min Lim ; Yu Ri Kim ; Jae Yong Cho ; Jae Yun Lim ; Gwang Won Rhee ; Ji Young Yun 
Citation
 Oncology, Vol.83(5) : 292~299, 2012 
Journal Title
 Oncology 
ISSN
 0030-2414 
Issue Date
2012
Abstract
OBJECTIVES: The objective of this study was to compare the usefulness of two inflammation-based prognostic scores, neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), assessed at diagnosis in stage IV advanced gastric cancer (AGC). METHODS: We retrospectively reviewed the medical records of 104 patients with newly diagnosed metastatic AGC treated with palliative chemotherapy. RESULTS: In the univariate analysis, the following variables were associated with shorter overall survival (OS): poor or undifferentiated histology (p = 0.013), more than 1 metastasis (p = 0.004), the presence of lymph node metastasis (p = 0.003), the presence of bone metastasis (p = 0.019), a lower albumin level (p < 0.001), elevated C-reactive protein (p < 0.001), a high absolute neutrophil count (p = 0.016), NLR ≥3 (p < 0.001) and higher mGPS (p < 0.001 and p = 0.007, respectively). In the multivariate analysis, high NLR and mGPS were independent prognostic factors for shorter OS (p = 0.037, p < 0.001 and p = 0.010, respectively), along with lymph node metastasis (p = 0.005) and histological subtype (p = 0.048). CONCLUSION: This study suggests that the inflammatory markers, NLR and mGPS, are independent prognostic factors for OS in patients with unresectable AGC treated with palliative chemotherapy. Copyright © 2012 S. Karger AG, Basel.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91584
DOI
10.1159/000342376
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.karger.com/Article/FullText/342376
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