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Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer

DC Field Value Language
dc.contributor.author김유리-
dc.contributor.author임선민-
dc.contributor.author임재윤-
dc.contributor.author조재용-
dc.date.accessioned2014-12-19T17:31:57Z-
dc.date.available2014-12-19T17:31:57Z-
dc.date.issued2012-
dc.identifier.issn0030-2414-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91584-
dc.description.abstractOBJECTIVES: The objective of this study was to compare the usefulness of two inflammation-based prognostic scores, neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), assessed at diagnosis in stage IV advanced gastric cancer (AGC). METHODS: We retrospectively reviewed the medical records of 104 patients with newly diagnosed metastatic AGC treated with palliative chemotherapy. RESULTS: In the univariate analysis, the following variables were associated with shorter overall survival (OS): poor or undifferentiated histology (p = 0.013), more than 1 metastasis (p = 0.004), the presence of lymph node metastasis (p = 0.003), the presence of bone metastasis (p = 0.019), a lower albumin level (p < 0.001), elevated C-reactive protein (p < 0.001), a high absolute neutrophil count (p = 0.016), NLR ≥3 (p < 0.001) and higher mGPS (p < 0.001 and p = 0.007, respectively). In the multivariate analysis, high NLR and mGPS were independent prognostic factors for shorter OS (p = 0.037, p < 0.001 and p = 0.010, respectively), along with lymph node metastasis (p = 0.005) and histological subtype (p = 0.048). CONCLUSION: This study suggests that the inflammatory markers, NLR and mGPS, are independent prognostic factors for OS in patients with unresectable AGC treated with palliative chemotherapy. Copyright © 2012 S. Karger AG, Basel.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use*-
dc.subject.MESHC-Reactive Protein/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGlasgow Outcome Scale-
dc.subject.MESHHemoglobins-
dc.subject.MESHHumans-
dc.subject.MESHInflammation/blood*-
dc.subject.MESHLeukocyte Count-
dc.subject.MESHLymphocytes-
dc.subject.MESHMale-
dc.subject.MESHMedical Records-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeutrophils-
dc.subject.MESHPalliative Care/methods*-
dc.subject.MESHPlatelet Count-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSerum Albumin/metabolism-
dc.subject.MESHStomach Neoplasms/blood*-
dc.subject.MESHStomach Neoplasms/drug therapy-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.titleComparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJae-Heon Jeong-
dc.contributor.googleauthorSun Min Lim-
dc.contributor.googleauthorJi Young Yun-
dc.contributor.googleauthorGwang Won Rhee-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorJae Yong Cho-
dc.contributor.googleauthorYu Ri Kim-
dc.identifier.doi22964877-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03369-
dc.contributor.localIdA03398-
dc.contributor.localIdA03899-
dc.contributor.localIdA00779-
dc.relation.journalcodeJ02416-
dc.identifier.eissn1423-0232-
dc.identifier.pmid22964877-
dc.identifier.urlhttp://www.karger.com/Article/FullText/342376-
dc.subject.keywordAdvanced gastric cancer-
dc.subject.keywordModified Glasgow Prognostic Score-
dc.subject.keywordNeutrophil to lymphocyte ratio-
dc.subject.keywordPrognostic factor-
dc.contributor.alternativeNameKim, Yu Ri-
dc.contributor.alternativeNameLim, Sun Min-
dc.contributor.alternativeNameLim, Jae Yun-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.affiliatedAuthorLim, Sun Min-
dc.contributor.affiliatedAuthorLim, Jae Yun-
dc.contributor.affiliatedAuthorCho, Jae Yong-
dc.contributor.affiliatedAuthorKim, Yu Ri-
dc.citation.volume83-
dc.citation.number5-
dc.citation.startPage292-
dc.citation.endPage299-
dc.identifier.bibliographicCitationONCOLOGY, Vol.83(5) : 292-299, 2012-
dc.identifier.rimsid29322-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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