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Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 김유리 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 임재윤 | - |
dc.contributor.author | 조재용 | - |
dc.date.accessioned | 2014-12-19T17:31:57Z | - |
dc.date.available | 2014-12-19T17:31:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91584 | - |
dc.description.abstract | OBJECTIVES: The objective of this study was to compare the usefulness of two inflammation-based prognostic scores, neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), assessed at diagnosis in stage IV advanced gastric cancer (AGC). METHODS: We retrospectively reviewed the medical records of 104 patients with newly diagnosed metastatic AGC treated with palliative chemotherapy. RESULTS: In the univariate analysis, the following variables were associated with shorter overall survival (OS): poor or undifferentiated histology (p = 0.013), more than 1 metastasis (p = 0.004), the presence of lymph node metastasis (p = 0.003), the presence of bone metastasis (p = 0.019), a lower albumin level (p < 0.001), elevated C-reactive protein (p < 0.001), a high absolute neutrophil count (p = 0.016), NLR ≥3 (p < 0.001) and higher mGPS (p < 0.001 and p = 0.007, respectively). In the multivariate analysis, high NLR and mGPS were independent prognostic factors for shorter OS (p = 0.037, p < 0.001 and p = 0.010, respectively), along with lymph node metastasis (p = 0.005) and histological subtype (p = 0.048). CONCLUSION: This study suggests that the inflammatory markers, NLR and mGPS, are independent prognostic factors for OS in patients with unresectable AGC treated with palliative chemotherapy. Copyright © 2012 S. Karger AG, Basel. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glasgow Outcome Scale | - |
dc.subject.MESH | Hemoglobins | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/blood* | - |
dc.subject.MESH | Leukocyte Count | - |
dc.subject.MESH | Lymphocytes | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Medical Records | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neutrophils | - |
dc.subject.MESH | Palliative Care/methods* | - |
dc.subject.MESH | Platelet Count | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Serum Albumin/metabolism | - |
dc.subject.MESH | Stomach Neoplasms/blood* | - |
dc.subject.MESH | Stomach Neoplasms/drug therapy | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.title | Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jae-Heon Jeong | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Ji Young Yun | - |
dc.contributor.googleauthor | Gwang Won Rhee | - |
dc.contributor.googleauthor | Jae Yun Lim | - |
dc.contributor.googleauthor | Jae Yong Cho | - |
dc.contributor.googleauthor | Yu Ri Kim | - |
dc.identifier.doi | 22964877 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A03398 | - |
dc.contributor.localId | A03899 | - |
dc.contributor.localId | A00779 | - |
dc.relation.journalcode | J02416 | - |
dc.identifier.eissn | 1423-0232 | - |
dc.identifier.pmid | 22964877 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/342376 | - |
dc.subject.keyword | Advanced gastric cancer | - |
dc.subject.keyword | Modified Glasgow Prognostic Score | - |
dc.subject.keyword | Neutrophil to lymphocyte ratio | - |
dc.subject.keyword | Prognostic factor | - |
dc.contributor.alternativeName | Kim, Yu Ri | - |
dc.contributor.alternativeName | Lim, Sun Min | - |
dc.contributor.alternativeName | Lim, Jae Yun | - |
dc.contributor.alternativeName | Cho, Jae Yong | - |
dc.contributor.affiliatedAuthor | Lim, Sun Min | - |
dc.contributor.affiliatedAuthor | Lim, Jae Yun | - |
dc.contributor.affiliatedAuthor | Cho, Jae Yong | - |
dc.contributor.affiliatedAuthor | Kim, Yu Ri | - |
dc.citation.volume | 83 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 292 | - |
dc.citation.endPage | 299 | - |
dc.identifier.bibliographicCitation | ONCOLOGY, Vol.83(5) : 292-299, 2012 | - |
dc.identifier.rimsid | 29322 | - |
dc.type.rims | ART | - |
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