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Functional and effective connectivity of anterior insula in anorexia nervosa and bulimia nervosa

Authors
 Kyung Ran Kim ; Jeonghun Ku ; Young-Chul Jung ; Hyeongrae Lee ; Jung-Hyun Lee 
Citation
 Neuroscience Letters, Vol.521(2) : 152~157, 2012 
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Issue Date
2012
Abstract
The anterior insula has been proposed to play a crucial role in eating disorders. However, it is still poorly understood how the anterior insula is involved in anorexia nervosa (AN) and bulimia nervosa (BN), which are characterized by opposite motivational responses to food. We applied a cue-reactivity paradigm using blood oxygen level-dependent functional magnetic resonance imaging in women with AN (N=18) and BN (N=20) and age-matched healthy controls (N=20). We defined the left anterior insula as a region-of-interest and performed seed-based functional connectivity and effective connectivity MRI analysis. In response to food images compared to non-food images, both the AN group and BN group demonstrated increased activity in the left anterior insula. In the AN group, the left anterior insula demonstrated significant interactions with the right insula and right inferior frontal gyrus. In the BN group, the left anterior insula demonstrated significant interactions with the medial orbitofrontal cortex. The distinct patterns of functional and effective connectivity of the anterior insula may contribute to the different clinical features of AN and BN.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91551
DOI
10.1016/j.neulet.2012.05.075
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Psychiatry
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0304394012007732
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