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Rapid recovery of tissue hypoxia by cotransplantation of endothelial cells

Authors
 Oh, Jinsoo  ;  Kim, Keung Nyun  ;  Yoon, Do Heum  ;  Han, Seong Rok  ;  Shin, Dong Ah  ;  Ha, Yoon 
Citation
 NEUROREPORT, Vol.23(11) : 658-662, 2012 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2012
MeSH
Animals ; Human Umbilical Vein Endothelial Cells/transplantation* ; Hypoxia/therapy ; Neovascularization, Physiologic* ; Neural Stem Cells/transplantation* ; Rats ; Spinal Cord Injuries/therapy* ; Stem Cell Transplantation/methods
Keywords
angiogenesis ; cotransplantation ; hypoxia ; spinal cord injury
Abstract
Disruption of blood vessels caused by a spinal cord injury leads to tissue hypoxia. This hypoxic condition reduces the survival of transplanted stem cells, consequentially decreasing the effectiveness of stem cell therapy. In this study, we investigated the correlation between angiogenesis and the survival of transplanted neural stem cells in a spinal cord injury model. Hypoxia-specific luciferase-expressing neural stem cells (EpoSV-Luc NSC) were used as a tool for the detection of hypoxia caused by a spinal cord injury. In vivo, angiogenesis by cotransplantation of endothelial cells quickly recovered tissue hypoxia caused by a spinal cord injury. As a result, cotransplantation of endothelial cells improved the survival of neural stem cells transplanted into the injured spinal cord.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201208010-00005&LSLINK=80&D=ovft
DOI
22705626
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keung Nyun(김긍년)
Shin, Dong Ah(신동아) ORCID logo https://orcid.org/0000-0002-5225-4083
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Ha, Yoon(하윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91545
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