Cited 0 times in
Rapid recovery of tissue hypoxia by cotransplantation of endothelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김긍년 | - |
dc.contributor.author | 신동아 | - |
dc.contributor.author | 윤도흠 | - |
dc.contributor.author | 하윤 | - |
dc.date.accessioned | 2014-12-19T17:30:42Z | - |
dc.date.available | 2014-12-19T17:30:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91545 | - |
dc.description.abstract | Disruption of blood vessels caused by a spinal cord injury leads to tissue hypoxia. This hypoxic condition reduces the survival of transplanted stem cells, consequentially decreasing the effectiveness of stem cell therapy. In this study, we investigated the correlation between angiogenesis and the survival of transplanted neural stem cells in a spinal cord injury model. Hypoxia-specific luciferase-expressing neural stem cells (EpoSV-Luc NSC) were used as a tool for the detection of hypoxia caused by a spinal cord injury. In vivo, angiogenesis by cotransplantation of endothelial cells quickly recovered tissue hypoxia caused by a spinal cord injury. As a result, cotransplantation of endothelial cells improved the survival of neural stem cells transplanted into the injured spinal cord. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Human Umbilical Vein Endothelial Cells/transplantation* | - |
dc.subject.MESH | Hypoxia/therapy | - |
dc.subject.MESH | Neovascularization, Physiologic* | - |
dc.subject.MESH | Neural Stem Cells/transplantation* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Spinal Cord Injuries/therapy* | - |
dc.subject.MESH | Stem Cell Transplantation/methods | - |
dc.title | Rapid recovery of tissue hypoxia by cotransplantation of endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Oh, Jinsoo | - |
dc.contributor.googleauthor | Kim, Keung Nyun | - |
dc.contributor.googleauthor | Yoon, Do Heum | - |
dc.contributor.googleauthor | Han, Seong Rok | - |
dc.contributor.googleauthor | Shin, Dong Ah | - |
dc.contributor.googleauthor | Ha, Yoon | - |
dc.identifier.doi | 22705626 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00331 | - |
dc.contributor.localId | A02092 | - |
dc.contributor.localId | A02546 | - |
dc.contributor.localId | A04255 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 22705626 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201208010-00005&LSLINK=80&D=ovft | - |
dc.subject.keyword | angiogenesis | - |
dc.subject.keyword | cotransplantation | - |
dc.subject.keyword | hypoxia | - |
dc.subject.keyword | spinal cord injury | - |
dc.contributor.alternativeName | Kim, Keung Nyun | - |
dc.contributor.alternativeName | Shin, Dong A | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.alternativeName | Ha, Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Keung Nyun | - |
dc.contributor.affiliatedAuthor | Shin, Dong A | - |
dc.contributor.affiliatedAuthor | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | Ha, Yoon | - |
dc.citation.volume | 23 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 658 | - |
dc.citation.endPage | 662 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.23(11) : 658-662, 2012 | - |
dc.identifier.rimsid | 29293 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.