3 174

Transplantation of an adipose stem cell cluster in a spinal cord injury

Authors
 Oh, Jin Soo  ;  Park, In Su  ;  Kim, Keung Nyun  ;  Yoon, Do Heum  ;  Kim, Sang-Heon  ;  Ha, Yoon 
Citation
 Neuroreport, Vol.23(5) : 277-282, 2012 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2012
Abstract
We investigated whether transplantation of a three-dimensional cell mass of adipose-derived stem cells (3DCM-ASCs) improved hind limb functional recovery by the stimulation of angiogenesis and neurogenesis in a spinal cord injury. In in-vitro experiments, we confirmed that 3DCM-ASCs differentiated into CD31-positive endothelial cells. To evaluate the therapeutic effect of 3DCM-ASCs in vivo, PBS, human adipose tissue-derived stem cells, and 3DCM-ASCs were transplanted into a spinal cord injury model. The 3DCM-ASCs transplanted into the injured spinal cord differentiated into CD31-positive endothelial cells and remained differentiated. Transplantation of 3DCM-ASCs into the injured spinal cord significantly elevated the density of vascular formations through angiogenic factors released by the 3DCM-ASCs at the lesion site, and enhanced axonal outgrowth at the lesion site. Consistent with these results, the transplantation of 3DCM-ASCs significantly improved functional recovery compared with both ASC transplantation and PBS treatment. These findings suggest that transplantation of 3DCM-ASCs may be an effective stem cell therapy for the treatment of spinal cord injuries and neural ischemia.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91543
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201203280-00003&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e3283505ae2
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김긍년(Kim, Keung Nyun)
오진수(Oh, Jin Soo)
윤도흠(Yoon, Do Heum)
하윤(Ha, Yoon)
Export
RIS (EndNote)
XLS (Excel)
XML
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse