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The effects of methane and hydrogen gases produced by enteric bacteria on ileal motility and colonic transit time

Authors
 J. Jahng  ;  I. S. Jung  ;  E. J. Choi  ;  J. L. Conklin  ;  H. Park 
Citation
 Neurogastroenterology and Motility, Vol.24(2) : 185-191, 2012 
Journal Title
 Neurogastroenterology and Motility 
ISSN
 1350-1925 
Issue Date
2012
Abstract
BACKGROUND: Gases produced by intestinal flora may modulate intestinal motor function in healthy individuals as well as those with functional bowel disease. Methane, produced by enteric bacteria in the human gut, is associated with slowed intestinal transit and constipation. The effects of hydrogen, another main gas produced by bacterial fermentation in the gut, on small bowel and colonic motor function remains unrecognized. Therefore, we set out to investigate whether intestinal gases including methane and hydrogen could influence the small bowel motility and colonic transit. METHODS: Guinea pig ileum was placed in the peristaltic bath with tension transducers attached to measure velocity and amplitude of peristaltic contraction before and after the infusion of control, hydrogen, and methane gases. Also, changes in the intraluminal pressures were monitored before and after the gas infusions. KEY RESULTS: Methane decreased peristaltic velocity and increased contraction amplitude significantly of guinea pig ileum (P < 0.05). The AUC of intraluminal pressure was significantly increased with methane in guinea pig ileum (P < 0.05). In a second experiment, guinea pig colon was placed in the peristaltic bath to measure transit time before and after control, hydrogen, methane, and methane-hydrogen mixture gas infusions. Hydrogen shortened colonic transit time by 47% in the proximal colon, and by 10% in the distal colon, when compared with baselines (P < 0.05). CONCLUSIONS & INFERENCES: Methane delayed ileal peristaltic conduction velocity by augmenting contractility. Hydrogen shortened colonic transit, and that effect was more prominent in the proximal colon than distal colon.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91525
DOI
10.1111/j.1365-2982.2011.01819.x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박효진(Park, Hyo Jin)
장재훈(Jahng, Jae Hoon)
정인수(Jung, In Su)
최은주(Choi, Eun Ju)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2011.01819.x/abstract
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