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Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis.

Authors
 SiHyun Cho  ;  Young Sik Choi  ;  Young Eun Jeon  ;  Kyung Jin Im  ;  Young Mi Choi  ;  Su Youn Yim  ;  HyeYeon Kim  ;  Seok Kyo Seo  ;  Byung Seok Lee 
Citation
 Microvascular Research, Vol.83(2) : 237-242, 2012 
Journal Title
 Microvascular Research 
ISSN
 0026-2862 
Issue Date
2012
Abstract
The aim of this study is to evaluate the expression of vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1) in peritoneal fluid (PF), peritoneal endometriotic lesions and eutopic endometrial tissues of patients with endometriosis. Peritoneal fluid, peritoneal endometriotic lesions and eutopic endometrial samples from patients with endometriosis, and peritoneal fluid, peritoneal tissue and endometrial samples from patients without endometriosis were obtained during an operative laparoscopy. The mean PF concentrations of VEGF and sFlt-1 were significantly higher in patients with endometriosis than in the controls. In the peritoneal tissue, the expressions of VEGF and sFlt-1 were significantly higher, where the expression of sFlt-1 in endometrium was significantly lower in patients with endometriosis. These findings indicate that not only abnormal expressions of angiogenic factors, but also aberrant expressions of antiangiogenic factors in the peritoneal and endometrial environment seem to be involved in the pathogenesis of endometriosis.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91459
DOI
10.1016/j.mvr.2011.12.004
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김혜연(Kim, Hye Yeon)
서석교(Seo, Seok Kyo)
이병석(Lee, Byung Seok)
임경진(Lim, Kyung Jin)
임수연(Yim, Su Youn)
전영은(Jeon, Young Eun)
조시현(Cho, Si Hyun)
최영미(Choi, Young Mi)
최영식(Choi, Young Sik)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0026286211002317
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